Linked Life Data

10658043

Source:http://linkedlifedata.com/resource/pubmed/id/10658043

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-3-3
pubmed:abstractText
Carbonic anhydrase (CA) inhibition is associated with a lower plasma lactate concentration ([La(-)](pl)), but the mechanism for this association is not known. The effect of CA inhibition on muscle high-energy phosphates [ATP and phosphocreatine (PCr)], lactate ([La(-)](m)), and glycogen was examined in seven men [28 +/- 3 (SE) yr] during cycling exercise under control (Con) and acute CA inhibition with acetazolamide (Acz; 10 mg/kg body wt iv). Subjects performed 6-min step transitions in work rate from 0 W to a work rate corresponding to approximately 50% of the difference between the O(2) uptake at the ventilatory threshold and peak O(2) uptake. Muscle biopsies were taken from the vastus lateralis at rest, at 30 min postinfusion, at end exercise (EE), and at 5 and 30 min postexercise. Arterialized venous blood was sampled from a dorsal hand vein and analyzed for [La(-)](pl). ATP was unchanged from rest values; no difference between Con and Acz was observed. The fall in PCr from rest [72 +/- 3 and 73 +/- 3.6 (SE) mmol/kg dry wt for Con and Acz, respectively] to EE (51 +/- 4 and 46 +/- 5 mmol/kg dry wt for Con and Acz, respectively) was similar in Con and Acz. At EE, glycogen (mmol glucosyl units/kg dry wt) decreased to similar values in Con and Acz (307 +/- 16 and 300 +/- 19, respectively). At EE, no difference was observed in [La(-)](m) between conditions (46 +/- 6 and 43 +/- 5 mmol/kg dry wt for Con and Acz, respectively). EE [La(-)](pl) was higher during Con than during Acz (11.4 +/- 1.0 vs. 8.2 +/- 0.6 mmol/l). The similar [La(-)](m) but lower [La(-)](pl) suggests that the uptake of La(-) by other tissues is enhanced after CA inhibition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
722-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10658043-Acetazolamide, pubmed-meshheading:10658043-Acid-Base Equilibrium, pubmed-meshheading:10658043-Acids, pubmed-meshheading:10658043-Adenosine Triphosphate, pubmed-meshheading:10658043-Adult, pubmed-meshheading:10658043-Alkalies, pubmed-meshheading:10658043-Carbonic Anhydrase Inhibitors, pubmed-meshheading:10658043-Diphosphates, pubmed-meshheading:10658043-Exercise, pubmed-meshheading:10658043-Glycogen, pubmed-meshheading:10658043-Heart Rate, pubmed-meshheading:10658043-Humans, pubmed-meshheading:10658043-Infusions, Intravenous, pubmed-meshheading:10658043-Lactates, pubmed-meshheading:10658043-Male, pubmed-meshheading:10658043-Muscle, Skeletal, pubmed-meshheading:10658043-Oxygen Consumption, pubmed-meshheading:10658043-Phosphates, pubmed-meshheading:10658043-Phosphocreatine, pubmed-meshheading:10658043-Pulmonary Gas Exchange
pubmed:year
2000
pubmed:articleTitle
Muscle metabolism during heavy-intensity exercise after acute acetazolamide administration.
pubmed:affiliation
Centre for Activity and Ageing, School of Kinesiology, The University of Western Ontario, London, Ontario N6A 3K7.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial, Research Support, Non-U.S. Gov't