Linked Life Data

10658024

Source:http://linkedlifedata.com/resource/pubmed/id/10658024

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pubmed-article:10658024pubmed:abstractTextSoleus muscle fibers were examined electron microscopically from pre- and postflight biopsies of four astronauts orbited for 17 days during the Life and Microgravity Sciences Spacelab Mission (June 1996). Myofilament density and spacing were normalized to a 2. 4-microm sarcomere length. Thick filament density ( approximately 1, 062 filaments/microm(2)) and spacing ( approximately 32.5 nm) were unchanged by spaceflight. Preflight thin filament density (2, 976/microm(2)) decreased significantly (P < 0.01) to 2,215/microm(2) in the overlap A band region as a result of a 17% filament loss and a 9% increase in short filaments. Normal fibers had 13% short thin filaments. The 26% decrease in thin filaments is consistent with preliminary findings of a 14% increase in the myosin-to-actin ratio. Lower thin filament density was calculated to increase thick-to-thin filament spacing in vivo from 17 to 23 nm. Decreased density is postulated to promote earlier cross-bridge detachment and faster contraction velocity. Atrophic fibers may be more susceptible to sarcomere reloading damage, because force per thin filament is estimated to increase by 23%.lld:pubmed
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pubmed-article:10658024pubmed:articleTitleDecreased thin filament density and length in human atrophic soleus muscle fibers after spaceflight.lld:pubmed
pubmed-article:10658024pubmed:affiliationDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee 53226, USA. dariley@mcw.edulld:pubmed
pubmed-article:10658024pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10658024pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:10658024pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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