Source:http://linkedlifedata.com/resource/pubmed/id/10658024
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2000-3-3
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pubmed:abstractText |
Soleus muscle fibers were examined electron microscopically from pre- and postflight biopsies of four astronauts orbited for 17 days during the Life and Microgravity Sciences Spacelab Mission (June 1996). Myofilament density and spacing were normalized to a 2. 4-microm sarcomere length. Thick filament density ( approximately 1, 062 filaments/microm(2)) and spacing ( approximately 32.5 nm) were unchanged by spaceflight. Preflight thin filament density (2, 976/microm(2)) decreased significantly (P < 0.01) to 2,215/microm(2) in the overlap A band region as a result of a 17% filament loss and a 9% increase in short filaments. Normal fibers had 13% short thin filaments. The 26% decrease in thin filaments is consistent with preliminary findings of a 14% increase in the myosin-to-actin ratio. Lower thin filament density was calculated to increase thick-to-thin filament spacing in vivo from 17 to 23 nm. Decreased density is postulated to promote earlier cross-bridge detachment and faster contraction velocity. Atrophic fibers may be more susceptible to sarcomere reloading damage, because force per thin filament is estimated to increase by 23%.
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pubmed:grant | |
pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/NASA Discipline Musculoskeletal,
http://linkedlifedata.com/resource/pubmed/keyword/NASA Experiment Number 8913020 1/2,
http://linkedlifedata.com/resource/pubmed/keyword/NASA Program Biomedical Research...,
http://linkedlifedata.com/resource/pubmed/keyword/NASA Program Fundamental Space...,
http://linkedlifedata.com/resource/pubmed/keyword/Non-NASA Center
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
8750-7587
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
567-72
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10658024-Actin Cytoskeleton,
pubmed-meshheading:10658024-Astronauts,
pubmed-meshheading:10658024-Humans,
pubmed-meshheading:10658024-Male,
pubmed-meshheading:10658024-Microscopy, Electron,
pubmed-meshheading:10658024-Muscle, Skeletal,
pubmed-meshheading:10658024-Muscle Fibers, Skeletal,
pubmed-meshheading:10658024-Muscular Atrophy,
pubmed-meshheading:10658024-Myofibrils,
pubmed-meshheading:10658024-Sarcomeres,
pubmed-meshheading:10658024-Space Flight,
pubmed-meshheading:10658024-Weightlessness
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pubmed:year |
2000
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pubmed:articleTitle |
Decreased thin filament density and length in human atrophic soleus muscle fibers after spaceflight.
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pubmed:affiliation |
Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee 53226, USA. dariley@mcw.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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