Source:http://linkedlifedata.com/resource/pubmed/id/10658021
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2000-3-3
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| pubmed:abstractText |
This paper describes and quantifies acute responses of the kidneys in correcting plasma volume, acid-base, and ion disturbances resulting from NaHCO(3) and KHCO(3) ingestion. Renal excretion of ions and water was studied in five men after ingestion of 3.57 mmol/kg body mass of sodium bicarbonate (NaHCO(3)) and, in a separate trial, potassium bicarbonate (KHCO(3)). Subjects had a Foley catheter inserted into the bladder and indwelling catheters placed into an antecubital vein and a brachial artery. Blood and urine were sampled in the 30-min period before, the 60-min period during, and the 210-min period after ingestion of the solutions. NaHCO(3) ingestion resulted in a rapid, transient diuresis and natriuresis. Cumulative urine output was 44 +/- 11% of ingested volume, resulting in a 555 +/- 119 ml increase in total body water at the end of the experiment. The cumulative increase (above basal levels) in renal Na(+) excretion accounted for 24 +/- 2% of ingested Na(+). In the KHCO(3) trial, arterial plasma K(+) concentration rapidly increased from 4.25 +/- 0.10 to a peak of 7.17 +/- 0.13 meq/l 140 min after the beginning of ingestion. This increase resulted in a pronounced, transient diuresis, with cumulative urine output at 270 min similar to the volume ingested, natriuresis, and a pronounced kaliuresis that was maintained until the end of the experiment. Cumulative (above basal) renal K(+) excretion at 270 min accounted for 26 +/- 5% of ingested K(+). The kidneys were important in mediating rapid corrections of substantial portions of the fluid and electrolyte disturbances resulting from ingestion of KHCO(3) and NaHCO(3) solutions.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Aldosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Alkalies,
http://linkedlifedata.com/resource/pubmed/chemical/Bicarbonates,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Electrolytes,
http://linkedlifedata.com/resource/pubmed/chemical/Lactates,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Quaternary Ammonium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Bicarbonate,
http://linkedlifedata.com/resource/pubmed/chemical/potassium bicarbonate
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
8750-7587
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
88
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
540-50
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10658021-Acid-Base Equilibrium,
pubmed-meshheading:10658021-Acids,
pubmed-meshheading:10658021-Administration, Oral,
pubmed-meshheading:10658021-Adult,
pubmed-meshheading:10658021-Aldosterone,
pubmed-meshheading:10658021-Alkalies,
pubmed-meshheading:10658021-Bicarbonates,
pubmed-meshheading:10658021-Calcium,
pubmed-meshheading:10658021-Electrolytes,
pubmed-meshheading:10658021-Glomerular Filtration Rate,
pubmed-meshheading:10658021-Humans,
pubmed-meshheading:10658021-Hydrogen-Ion Concentration,
pubmed-meshheading:10658021-Kidney,
pubmed-meshheading:10658021-Lactates,
pubmed-meshheading:10658021-Male,
pubmed-meshheading:10658021-Potassium,
pubmed-meshheading:10658021-Potassium Compounds,
pubmed-meshheading:10658021-Quaternary Ammonium Compounds,
pubmed-meshheading:10658021-Sodium,
pubmed-meshheading:10658021-Sodium Bicarbonate,
pubmed-meshheading:10658021-Urination,
pubmed-meshheading:10658021-Urodynamics,
pubmed-meshheading:10658021-Water-Electrolyte Balance
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| pubmed:year |
2000
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| pubmed:articleTitle |
NaHCO(3) and KHCO(3) ingestion rapidly increases renal electrolyte excretion in humans.
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| pubmed:affiliation |
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph N1G 2W1, Canada L8N 3Z5. mlindinger.ns@aps.uoguelph.ca
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|