Linked Life Data

10657505

Source:http://linkedlifedata.com/resource/pubmed/id/10657505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-6-1
pubmed:abstractText
Intraplantar injection of carrageenan induced significant Fos expression in the superficial and deep spinal dorsal horn at the L(4)-L(5)segments and extensive peripheral edema of the ipsilateral foot in rats. Intraplantar injection of endomorphin-1, endogenous ligand for mu opioid receptor, in the same region produced dose-dependent reduction of carrageenan-induced Fos expression and peripheral edema, which were completely blocked by co-administration of intraplantar injection of naloxone (20 microgram). The systemic injection of the highest dose of endomorphin-1 (50 microgram) had no significant reductory effect on Fos expression and peripheral edema. These results further provided a strong evidence for involvement of mu opioid receptor in peripheral analgesia, particularly in inflammation pain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0143-4179
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Harcourt Publishers Ltd.
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Endomorphin-1 reduces carrageenan-induced fos expression in the rat spinal dorsal horn.
pubmed:affiliation
Shanghai Brain Research Institute, Chinese Academy of Sciences, Shanghai, 200031, China. zhoa@iris.shlc.ac.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't