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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-3-10
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pubmed:abstractText |
TLS (also known as FUS) is an RNA-binding protein that contributes the N-terminal half of fusion oncoproteins implicated in the development of human liposarcomas and leukemias. Here we report that male mice homozygous for an induced mutation in TLS are sterile with a marked increase in the number of unpaired and mispaired chromosomal axes in pre-meiotic spermatocytes. Nuclear extracts from TLS(-/-) testes lack an activity capable of promoting pairing between homologous DNA sequences in vitro, and TLS(-/-) mice and embryonic fibroblasts exhibit increased sensitivity to ionizing irradiation. These results are consistent with a role for TLS in homologous DNA pairing and recombination.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-10220412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-10442642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-10567410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-1522903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-3698747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-5833946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-7503811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-7520527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-7585257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-7623847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-7651539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-7828807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-7878049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-7958914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-7969446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-7970732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-8246959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-8367282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-8510758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-8650194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-8676928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-8890175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9066264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9088645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9209098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9264461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9284822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9287344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9288969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9391070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9440806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9443891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9449642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9482885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9488465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9583675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9660919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9687511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10654943-9704926
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0261-4189
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pubmed:author |
pubmed-author:AkhmedovAA,
pubmed-author:AshleyTT,
pubmed-author:BaechtoldHH,
pubmed-author:ChungPP,
pubmed-author:KurodaMM,
pubmed-author:RoyII,
pubmed-author:SomTT,
pubmed-author:UranoFF,
pubmed-author:WebbLL,
pubmed-author:YinYY,
pubmed-author:de RooijD GDG
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
453-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10654943-Genitalia,
pubmed-meshheading:10654943-Infertility,
pubmed-meshheading:10654943-Spermatozoa,
pubmed-meshheading:10654943-Testis,
pubmed-meshheading:10654943-Animals,
pubmed-meshheading:10654943-Mice,
pubmed-meshheading:10654943-Ultraviolet Rays,
pubmed-meshheading:10654943-Embryo, Mammalian,
pubmed-meshheading:10654943-Female,
pubmed-meshheading:10654943-Male,
pubmed-meshheading:10654943-Ribonucleoproteins,
pubmed-meshheading:10654943-Radiation, Ionizing,
pubmed-meshheading:10654943-RNA,
pubmed-meshheading:10654943-Fibroblasts,
pubmed-meshheading:10654943-Chromosome Aberrations,
pubmed-meshheading:10654943-RNA, Messenger,
pubmed-meshheading:10654943-Chromosome Disorders,
pubmed-meshheading:10654943-Recombination, Genetic,
pubmed-meshheading:10654943-Radiation Tolerance
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