Linked Life Data

10654104

Source:http://linkedlifedata.com/resource/pubmed/id/10654104

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-3-2
pubmed:abstractText
In the first half of the century, histological abnormalities in the cortex and thalamus of schizophrenics were described. These findings, however, remained controversial and finally were widely forgotten. More recently, a large number of structural imaging studies convincingly showed subtle structural changes such as ventricular enlargement, cortical sulcal enlargement, and smaller hippocampi in a considerable proportion of schizophrenic patients. Many studies reported minor tissue abnormalities in limbic structures. Since the limbic system is anatomically and functionally interposed between the neocortical association areas and phylogenetically old hypothalamic and brain stem systems, limbic dysfunction may lead to a dissociation between cognitive activities and basic emotional reactions, thus, explaining some aspects of the psychopathology of schizophrenia. Reduced cortical asymmetry, lack of gliosis, and other findings support the idea of a disorder of early brain development; however, a progressive component also might be inherent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0940-1334
pubmed:author
pubmed:issnType
Print
pubmed:volume
249 Suppl 4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2-13
pubmed:dateRevised
2009-5-11
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
The neuropathology of schizophrenic diseases: historical aspects and present knowledge.
pubmed:affiliation
Department of Psychiatry, University of Magdeburg, Germany.
pubmed:publicationType
Journal Article, Review, Historical Article