Source:http://linkedlifedata.com/resource/pubmed/id/10653595
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-2-10
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pubmed:abstractText |
We studied monoamine oxidase (MAO) A and B localization in human pancreas, thyroid gland, and adrenal gland by immunohistochemistry. The primary antibodies used were mouse monoclonal anti-human MAO-A (6G11/E1) and anti-human MAO-B (3F12/G10/2E3). Samples were obtained from six routine autopsy cases and fixed in 2% paraformaldehyde. Exocrine pancreas showed a widespread distribution of MAO-A, whereas MAO-B was present only in centroacinar cells and epithelial cells of pancreatic ducts. In endocrine pancreas, MAO-A was observed in around 50% of islet cells, whereas MAO-B was less abundant and was restricted to the periphery of islets. Thyroid gland showed strong MAO-A immunoreactivity in all cell types and was MAO-B-negative. In adrenal gland, the capsule displayed MAO-A but not MAO-B immunoreactivity, whereas the cortex showed widespread MAO-A staining but was MAO-B-negative in interstitial cells. Finally, in the medulla only a few scattered cells showed either MAO-A or MAO-B immunoreactivity. To our knowledge, these data represent the first study of the cellular distribution of MAO-A and MAO-B in the three human tissues included.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1554
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
147-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10653595-Adrenal Glands,
pubmed-meshheading:10653595-Aged,
pubmed-meshheading:10653595-Aged, 80 and over,
pubmed-meshheading:10653595-Antibody Specificity,
pubmed-meshheading:10653595-Female,
pubmed-meshheading:10653595-Humans,
pubmed-meshheading:10653595-Immunohistochemistry,
pubmed-meshheading:10653595-Islets of Langerhans,
pubmed-meshheading:10653595-Isoenzymes,
pubmed-meshheading:10653595-Male,
pubmed-meshheading:10653595-Middle Aged,
pubmed-meshheading:10653595-Monoamine Oxidase,
pubmed-meshheading:10653595-Pancreas,
pubmed-meshheading:10653595-Thyroid Gland
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pubmed:year |
2000
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pubmed:articleTitle |
Localization of monoamine oxidase A and B in human pancreas, thyroid, and adrenal glands.
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pubmed:affiliation |
Unitat de Bioquímica, Facultat de Medicina, Universitat de Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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