Linked Life Data

10652610

Source:http://linkedlifedata.com/resource/pubmed/id/10652610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4B
pubmed:dateCreated
2000-2-15
pubmed:abstractText
To identify retinoic acid (RA) signalling pathways involved in growth and differentiation in cells of the glial lineage, two human glioma ceh lines were studied. The three RA receptors (RARs) mRNAs were constitutively expressed, and of the three RXRs, RXR beta appeared predominant. Western blotting analysis confirmed the constitutive expression of RAR alpha and RAR beta. Treatment with all-trans-RA induced morphological changes in the two cell lines, which progressed from their normal pattern of randomly oriented spindle-shaped cells to fibroblast-like glial cells. RA up-regulated RAR alpha and RAR beta mRNAs in both cell lines. Interestingly, RA treatment up-regulated RAR beta proteins but not RAR alpha proteins, suggesting post-transcriptional regulations of RAR transcripts in glioma cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3189-92
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Retinoic acid modulates RAR alpha and RAR beta receptors in human glioma cell lines.
pubmed:affiliation
Laboratoire de Biologie Cellulaire Hématopoiétique, Institut d'Hématologie, Hôpital Saint-Louis, Paris, France. acarpent@club-internet.fr
pubmed:publicationType
Journal Article