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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-3-9
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pubmed:abstractText |
Advanced glycation end product-modified beta2-microglobulin (AGE-beta2m) is an important component of dialysis-related amyloidosis (DRA). Its presence induces monocyte chemotaxis and the release of the proinflammatory cytokines through macrophage activation. Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that also has chemotactic activity for monocytes at very low (0.1 to 10 pg/mL) concentrations and inhibits proinflammatory cytokine production of macrophages. In this study, we investigated the role of TGF-beta in the pathogenesis of DRA.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glycosylation End Products, Advanced,
http://linkedlifedata.com/resource/pubmed/chemical/IL1RN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
697-708
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10652049-Aged,
pubmed-meshheading:10652049-Amyloidosis,
pubmed-meshheading:10652049-Cells, Cultured,
pubmed-meshheading:10652049-Chemotaxis,
pubmed-meshheading:10652049-Chronic Disease,
pubmed-meshheading:10652049-Female,
pubmed-meshheading:10652049-Glycosylation End Products, Advanced,
pubmed-meshheading:10652049-Humans,
pubmed-meshheading:10652049-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:10652049-Kidney Failure, Chronic,
pubmed-meshheading:10652049-Macrophages,
pubmed-meshheading:10652049-Male,
pubmed-meshheading:10652049-Middle Aged,
pubmed-meshheading:10652049-Monocytes,
pubmed-meshheading:10652049-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:10652049-Renal Dialysis,
pubmed-meshheading:10652049-Sialoglycoproteins,
pubmed-meshheading:10652049-Synovial Membrane,
pubmed-meshheading:10652049-Transforming Growth Factor beta,
pubmed-meshheading:10652049-Tumor Necrosis Factor-alpha,
pubmed-meshheading:10652049-beta 2-Microglobulin
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pubmed:year |
2000
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pubmed:articleTitle |
Transforming growth factor-beta is involved in the pathogenesis of dialysis-related amyloidosis.
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pubmed:affiliation |
Department of Medicine, Division of Nephrology, Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232-2372, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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