Source:http://linkedlifedata.com/resource/pubmed/id/10651518
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3 Suppl 3
|
pubmed:dateCreated |
2000-1-24
|
pubmed:abstractText |
Orthotopic liver transplantation survival for patients with acute liver failure is poor (50%). Mortality on the waiting list is high due to the lack of donors. For these reasons, the possibility of sustaining hepatic function by extra-corporeal liver perfusion must be considered. In this experimental research, two groups of pigs have been submitted to total de-vascularisation of the liver causing acute hepatic failure. In the first group (4 pigs) no extra-corporeal assistance has been used after total de-vascularisation. All pigs died between 16 and 33 hours after the acute hepatic failure was induced. In the second group (8 pigs) after complete hepatic de-vascularisation an extra-corporeal hepatic support by continuous allo-perfusion of isolated liver was performed using the Abouna-Costa extra-corporeal circuit. All pigs were observed during the acute hepatic failure which lasted from 6.30 to 7.30 hours. The data that were more positively influenced by the extra-corporeal assistance were ammonia and lactates that improved after the application of hepatic assistance.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:issn |
1121-8142
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
67-73
|
pubmed:dateRevised |
2003-11-14
|
pubmed:meshHeading | |
pubmed:articleTitle |
Biotechnologies and acute hepatic failure.
|
pubmed:affiliation |
Istituto di Chirurgia Sperimentale e dei Trapianti, Università di Milano, Unità Operativa per il Trapianto e la Chirurgia del Fegato e del Polmone, Ospedale Maggiore IRCCS, Milano.
|
pubmed:publicationType |
Journal Article
|