Source:http://linkedlifedata.com/resource/pubmed/id/10651203
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
2000-2-14
|
pubmed:abstractText |
Endothelin-1 (ET-1) is a potent vasoconstrictor peptide produced by vascular endothelial cells. However, the role of ET-1 in exercise-induced physiological responses is still to be investigated. The purpose of the present study was to investigate in healthy volunteers whether the ET-1 plasma concentration in nonworking muscles is changed by exercise and to investigate the physiological role of ET-1 during exercise. Bicycle ergometer cardiopulmonary exercise tests were performed in 36 healthy men (mean age, 22.5 years). Blood samples for measuring ET-1 were drawn from the cubital vein during rest and immediately after the exercise test. The ET-1 change ratio was calculated as ET-1 immediately following exercise/ET-1 during the resting state. Cardiac output (CO) was measured during the exercise test by the impedance method. Arterial venous oxygen difference (AVO2D) when CO reached 10L/min or 15L/min was calculated as AVO2D = VO2/CO. Results were as follows: (1) the ET-1 change ratio correlated inversely with exercise time at the anaerobic threshold (r = -0.37, p = 0.03) and peak exercise time (r = -0.35, p = 0.04); (2) the ET-1 change ratio tended toward an inverse correlation with deltaVO2/deltawork rate (r = -0.29, p = 0.09); (3) the ET-1 change ratio correlated positively with AVO2D when CO reached 10L/min (r = 0.42, p = 0.02) and tended toward a positive correlation with AVO2D when CO reached 15 L/min (r = 0.32, p = 0.08). These results indicate that an increase in ET-1 in nonworking muscles may participate in the exercise-induced redistribution of blood flow and in increasing the blood flow to working muscles.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0047-1828
|
pubmed:author |
pubmed-author:AkashiYY,
pubmed-author:ItohHH,
pubmed-author:Miyama,
pubmed-author:MurabayashiTT,
pubmed-author:MurayamaMM,
pubmed-author:NakayamaMM,
pubmed-author:OmiyaKK,
pubmed-author:OsadaNN,
pubmed-author:OyaMM,
pubmed-author:RANDE OEO,
pubmed-author:SamejimaHH,
pubmed-author:SuzukiNN,
pubmed-author:TanabeKK,
pubmed-author:YamamotoAA,
pubmed-author:YokoyamaYY
|
pubmed:issnType |
Print
|
pubmed:volume |
64
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
27-31
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:10651203-Adult,
pubmed-meshheading:10651203-Blood Pressure,
pubmed-meshheading:10651203-Cardiac Output,
pubmed-meshheading:10651203-Endothelin-1,
pubmed-meshheading:10651203-Exercise,
pubmed-meshheading:10651203-Exercise Test,
pubmed-meshheading:10651203-Heart Rate,
pubmed-meshheading:10651203-Hemodynamics,
pubmed-meshheading:10651203-Humans,
pubmed-meshheading:10651203-Male,
pubmed-meshheading:10651203-Muscle, Skeletal,
pubmed-meshheading:10651203-Oxygen,
pubmed-meshheading:10651203-Physical Exertion,
pubmed-meshheading:10651203-Reference Values,
pubmed-meshheading:10651203-Regression Analysis,
pubmed-meshheading:10651203-Rest
|
pubmed:year |
2000
|
pubmed:articleTitle |
Physiological role of endothelin-1 in nonworking muscles during exercise in healthy subjects.
|
pubmed:affiliation |
Department of Cardiology, St Marianna University School of Medicine, Kawasaki, Japan.
|
pubmed:publicationType |
Journal Article
|