Linked Life Data

10651151

Source:http://linkedlifedata.com/resource/pubmed/id/10651151

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-2-17
pubmed:abstractText
Nociceptin (or orphanin FQ), the endogenous ligand for the opioid receptor-like 1 (ORL1) receptor, decreases blood pressure in the conscious and anesthetized rat. This study examined whether prejunctional inhibitory ORL1 receptors located on the postganglionic sympathetic neurons innervating the resistance vessels are detectable in pithed rats. In pithed and vagotomized rats electrical stimulation of the preganglionic sympathetic nerve fibers, injection of nicotine (2 micromol/kg) or noradrenaline (1 nmol/kg) increased blood pressure by about 30 mmHg. The electrically induced vasopressor response was decreased dose-dependently by nociceptin (0.001-1 micromol/kg; decrease by about 60% at 1 micromol/kg). Nociceptin 0.1 micromol/kg reduced the nicotine-induced vasopressor response by about 40% but at doses up to 1 micromol/kg failed to affect the increase in blood pressure evoked by noradrenaline. The inhibitory action of nociceptin on the electrically and nicotine-induced increase in blood pressure was attenuated by the ORL1 receptor antagonists naloxone benzoylhydrazone (5 micromol/kg) and/or [Phe1psi(CH2-NH)Gly2]-nociceptin(1-13)NH2 (1 micromol/kg) but was not affected by naloxone 10 micromol/kg. In conclusion, the present data suggest that the postganglionic sympathetic nerve fibers innervating the resistance vessels of the rat are endowed with prejunctional ORL1 receptors, activation of which causes inhibition of noradrenaline release.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0028-1298
pubmed:author
pubmed:issnType
Print
pubmed:volume
361
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
80-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10651151-Animals, pubmed-meshheading:10651151-Autonomic Fibers, Preganglionic, pubmed-meshheading:10651151-Blood Pressure, pubmed-meshheading:10651151-Decerebrate State, pubmed-meshheading:10651151-Electric Stimulation, pubmed-meshheading:10651151-Male, pubmed-meshheading:10651151-Naloxone, pubmed-meshheading:10651151-Narcotic Antagonists, pubmed-meshheading:10651151-Nervous System Physiological Phenomena, pubmed-meshheading:10651151-Neuromuscular Junction, pubmed-meshheading:10651151-Nicotine, pubmed-meshheading:10651151-Nicotinic Agonists, pubmed-meshheading:10651151-Norepinephrine, pubmed-meshheading:10651151-Opioid Peptides, pubmed-meshheading:10651151-Rats, pubmed-meshheading:10651151-Rats, Wistar, pubmed-meshheading:10651151-Receptors, Opioid, pubmed-meshheading:10651151-Sympathomimetics, pubmed-meshheading:10651151-Vagotomy
pubmed:year
2000
pubmed:articleTitle
Nociceptin inhibits the neurogenic vasopressor response in the pithed rat via prejunctional ORL1 receptors.
pubmed:affiliation
Department of Experimental Physiology, Medical Academy, Bia?ystok, Poland. bmalin@cksr.ac.bialystok.pl
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't