Source:http://linkedlifedata.com/resource/pubmed/id/10651082
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2000-2-17
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| pubmed:abstractText |
This study proposed to investigate the prevalence and clinical relevance of serum immunoglobulin A (IgA) rheumatoid factor (RF) in juvenile rheumatoid arthritis (JRA) as published reports vary in their conclusion. Sera of 82 children with JRA and 25-age and sex-matched healthy children were measured for IgA RF by an enzyme linked immunoassay using human IgG as the antigen. Forty-three percent of the disease population were positive and the prevalence in pauciarticular, polyarticular and systemic onset was 9/18 (50%), 21/47 (44.7%) and 5/17 (27.7%) respectively when mean + 2SD of normal was taken as the cut-off value. By defining the upper limit of normal as mean + 6SD, 16/47 (34%) were positive in the polyarticular as compared to 2/18 (11.1%) in pauciarticular and 1/17 (5.8%) of systemic onset disease groups. The prevalence in the polyarticular subset with the upper cut-off limit was significantly higher than the pauciarticular and the systemic onset group (P < 0.05). Furthermore, the mean level of IgA RF was significantly higher in the polyarticular group compared to the mean level in the systemic onset group (P < 0.05). The mean level of IgA RF was also significantly higher (P < 0.05) in 61 children with active diseases.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0172-8172
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
19
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
47-9
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10651082-Adolescent,
pubmed-meshheading:10651082-Arthritis, Juvenile Rheumatoid,
pubmed-meshheading:10651082-Child,
pubmed-meshheading:10651082-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10651082-Female,
pubmed-meshheading:10651082-Humans,
pubmed-meshheading:10651082-Immunoglobulin A,
pubmed-meshheading:10651082-Male,
pubmed-meshheading:10651082-Rheumatoid Factor
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| pubmed:year |
1999
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| pubmed:articleTitle |
Clinical relevance of IgA rheumatoid factor (RF) in children with juvenile rheumatoid arthritis.
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| pubmed:affiliation |
Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
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| pubmed:publicationType |
Journal Article
|