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| pubmed-article:10649995 | lifeskim:mentions | umls-concept:C0017258 | lld:lifeskim |
| pubmed-article:10649995 | lifeskim:mentions | umls-concept:C1136012 | lld:lifeskim |
| pubmed-article:10649995 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10649995 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10649995 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10649995 | pubmed:issue | 5453 | lld:pubmed |
| pubmed-article:10649995 | pubmed:dateCreated | 2000-2-18 | lld:pubmed |
| pubmed-article:10649995 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10649995 | pubmed:abstractText | The polyketide epothilone is a potential anticancer agent that stabilizes microtubules in a similar manner to Taxol. The gene cluster responsible for epothilone biosynthesis in the myxobacterium Sorangium cellulosum was cloned and completely sequenced. It encodes six multifunctional proteins composed of a loading module, one nonribosomal peptide synthetase module, eight polyketide synthase modules, and a P450 epoxidase that converts desoxyepothilone into epothilone. Concomitant expression of these genes in the actinomycete Streptomyces coelicolor produced epothilones A and B. Streptomyces coelicolor is more amenable to strain improvement and grows about 10-fold as rapidly as the natural producer, so this heterologous expression system portends a plentiful supply of this important agent. | lld:pubmed |
| pubmed-article:10649995 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10649995 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10649995 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10649995 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10649995 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10649995 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10649995 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:10649995 | pubmed:author | pubmed-author:KatzLL | lld:pubmed |
| pubmed-article:10649995 | pubmed:author | pubmed-author:ShahSS | lld:pubmed |
| pubmed-article:10649995 | pubmed:author | pubmed-author:TangLL | lld:pubmed |
| pubmed-article:10649995 | pubmed:author | pubmed-author:CarneyJJ | lld:pubmed |
| pubmed-article:10649995 | pubmed:author | pubmed-author:ChungLL | lld:pubmed |
| pubmed-article:10649995 | pubmed:author | pubmed-author:KhoslaCC | lld:pubmed |
| pubmed-article:10649995 | pubmed:author | pubmed-author:JulienBB | lld:pubmed |
| pubmed-article:10649995 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10649995 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:10649995 | pubmed:volume | 287 | lld:pubmed |
| pubmed-article:10649995 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10649995 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10649995 | pubmed:pagination | 640-2 | lld:pubmed |
| pubmed-article:10649995 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10649995 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10649995 | pubmed:articleTitle | Cloning and heterologous expression of the epothilone gene cluster. | lld:pubmed |
| pubmed-article:10649995 | pubmed:affiliation | KOSAN Biosciences, 3832 Bay Center Place, Hayward, CA 94545, USA. | lld:pubmed |
| pubmed-article:10649995 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10649995 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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