pubmed-article:10648399 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10648399 | lifeskim:mentions | umls-concept:C0919490 | lld:lifeskim |
pubmed-article:10648399 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
pubmed-article:10648399 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
pubmed-article:10648399 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
pubmed-article:10648399 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
pubmed-article:10648399 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
pubmed-article:10648399 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:10648399 | pubmed:dateCreated | 2000-2-24 | lld:pubmed |
pubmed-article:10648399 | pubmed:abstractText | The ets-family transcription factor PU.1 is required for the proper development of both myeloid and lymphoid progenitors. We used PU. 1-deficient animals to examine the role of PU.1 during dendritic cell development. PU.1(-/-)animals produce lymphoid-derived dendritic cells (DC): low-density class II major histocompatibility complex [MHC-II(+)] CD11c(+) CD8alpha(+) DEC-205(+). But they lack myeloid-derived DC: low-density MHC-II(+) CD11c(+) CD8alpha(-) DEC-205(-). PU.1(-/-) embryos also lack progenitors capable of differentiating into myeloid DC in response to granulocyte-macrophage colony-stimulating factor plus interleukin-4. The appearance of lymphoid DC in developing PU.1(-/-)thymus was initially delayed, but this population recovered to wild type (WT) levels upon organ culture of isolated thymic lobes. PU. 1(-/-)lymphoid DC were functionally equivalent to WT DC for stimulating T-cell proliferation in mixed lymphocyte reactions. These results demonstrate that PU.1 is required for the development of myeloid DC but not lymphoid DC. | lld:pubmed |
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pubmed-article:10648399 | pubmed:language | eng | lld:pubmed |
pubmed-article:10648399 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10648399 | pubmed:citationSubset | AIM | lld:pubmed |
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pubmed-article:10648399 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10648399 | pubmed:month | Feb | lld:pubmed |
pubmed-article:10648399 | pubmed:issn | 0006-4971 | lld:pubmed |
pubmed-article:10648399 | pubmed:author | pubmed-author:GuerrieroAA | lld:pubmed |
pubmed-article:10648399 | pubmed:author | pubmed-author:SpainL MLM | lld:pubmed |
pubmed-article:10648399 | pubmed:author | pubmed-author:ScottE WEW | lld:pubmed |
pubmed-article:10648399 | pubmed:author | pubmed-author:LangmuirP BPB | lld:pubmed |
pubmed-article:10648399 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10648399 | pubmed:day | 1 | lld:pubmed |
pubmed-article:10648399 | pubmed:volume | 95 | lld:pubmed |
pubmed-article:10648399 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10648399 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10648399 | pubmed:pagination | 879-85 | lld:pubmed |
pubmed-article:10648399 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:10648399 | pubmed:year | 2000 | lld:pubmed |
pubmed-article:10648399 | pubmed:articleTitle | PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. | lld:pubmed |
pubmed-article:10648399 | pubmed:affiliation | Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA 19104-6140, USA. | lld:pubmed |
pubmed-article:10648399 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10648399 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:10648399 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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