Linked Life Data

10648128

Source:http://linkedlifedata.com/resource/pubmed/id/10648128

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pubmed-article:10648128pubmed:abstractTextPeritoneal cavity cells were isolated from IL6-gene knockout (IL6(-/-)) and wild-type mice and stained for expression of IgM, CD5, and CD23. B1 cell (IgM(+)/CD23(-), CD5(+)/IgM(+)) numbers were increased twofold in IL6(-/-) mice compared to normals while IgM(+)/CD23(+) (B2) cell numbers were reduced threefold. Intestinal antibody levels were also determined for both total immunoglobulin and phosphorylcholine (PC)-specific and LPS-specific antibody following oral challenge with attenuated Salmonella typhimurium. Total immunoglobulin levels (IgM, IgG, and IgA) were reduced 60-80% in intestinal secretions of IL6(-/-) mice compared to wild-type controls; however, PC-specific antibody was significantly higher in IL6(-/-) mice. Anti-LPS antibodies were also three- to sevenfold higher in IL6(-/-) mice compared to controls following Salmonella challenge. These data suggest that in IL6(-/-) mice the development of mucosal B2 cells is impaired but that intestinal B1 cells responding to microbial antigens such as PC and LPS develop normally and are fully functional.lld:pubmed
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pubmed-article:10648128pubmed:authorpubmed-author:HusbandA JAJlld:pubmed
pubmed-article:10648128pubmed:authorpubmed-author:BeagleyK WKWlld:pubmed
pubmed-article:10648128pubmed:copyrightInfoCopyright 1999 Academic Press.lld:pubmed
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pubmed-article:10648128pubmed:pagination139-42lld:pubmed
pubmed-article:10648128pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10648128pubmed:articleTitleB1 B cell numbers and antibodies against phosphorylcholine and LPS are increased in IL-6 gene knockout mice.lld:pubmed
pubmed-article:10648128pubmed:affiliationDiscipline of Immunology and Microbiology, University of Newcastle, Callaghan, NSW 2308, Australia.lld:pubmed
pubmed-article:10648128pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10648128pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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