| pubmed-article:10646532 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10646532 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10646532 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:10646532 | lifeskim:mentions | umls-concept:C1720776 | lld:lifeskim |
| pubmed-article:10646532 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:10646532 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10646532 | pubmed:dateCreated | 2000-2-10 | lld:pubmed |
| pubmed-article:10646532 | pubmed:abstractText | We investigated the role of nitric oxide (NO) and brain-derived neurotrophic factor (BDNF) in the pentylenetetrazole (PTZ)-induced kindling in rats. Seizures were induced by single administration of PTZ, which was associated with an increase in levels of NO metabolites (NOx) in the hippocampus. Pretreatment with a neuronal NO synthase inhibitor, 7-nitroindazole (7-NI), diminished the PTZ-induced increase in NOx levels without affecting the seizure intensity. Repeated administration of PTZ produced a gradual increase in the seizure intensity, leading to the development of kindling. In the kindled rats, PTZ at a dose of 40 mg/kg increased NOx levels in the hippocampus, whereas it had no effect in control animals. Cotreatment of 7-NI with PTZ blocked the development of kindling and attenuated the PTZ-induced increase in NOx levels. A significant increase in BDNF levels was observed in the hippocampus of the kindled rats, which returned to the control levels following seizures induced by PTZ. 7-NI reduced the hippocampal BDNF levels in control rats and suppressed the increase of BDNF levels in the kindled rats. Our findings suggest that NO plays a role in the development of PTZ-induced kindling and that BDNF may contribute to the NO-dependent plastic changes in neuronal excitability. | lld:pubmed |
| pubmed-article:10646532 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10646532 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10646532 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10646532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10646532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10646532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10646532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10646532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10646532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10646532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10646532 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10646532 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10646532 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:10646532 | pubmed:author | pubmed-author:YamadaKK | lld:pubmed |
| pubmed-article:10646532 | pubmed:author | pubmed-author:NabeshimaTT | lld:pubmed |
| pubmed-article:10646532 | pubmed:author | pubmed-author:HaqII | lld:pubmed |
| pubmed-article:10646532 | pubmed:author | pubmed-author:XiongHH | lld:pubmed |
| pubmed-article:10646532 | pubmed:author | pubmed-author:NawaHH | lld:pubmed |
| pubmed-article:10646532 | pubmed:author | pubmed-author:SenzakiKK | lld:pubmed |
| pubmed-article:10646532 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10646532 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:10646532 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10646532 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10646532 | pubmed:pagination | 792-8 | lld:pubmed |
| pubmed-article:10646532 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10646532 | pubmed:meshHeading | pubmed-meshheading:10646532... | lld:pubmed |
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| pubmed-article:10646532 | pubmed:meshHeading | pubmed-meshheading:10646532... | lld:pubmed |
| pubmed-article:10646532 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10646532 | pubmed:articleTitle | Involvement of nitric oxide in pentylenetetrazole-induced kindling in rats. | lld:pubmed |
| pubmed-article:10646532 | pubmed:affiliation | Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan. | lld:pubmed |
| pubmed-article:10646532 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10646532 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
