Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 2
pubmed:dateCreated
2000-2-29
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192887, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192888, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192889, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192890, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192891, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192892, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192893, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192894, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192895, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192896, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192897, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192898, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192899, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192900, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192901, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192902, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192903, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192904, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192905, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192906, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192907, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192908, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF192909
pubmed:abstractText
Chikungunya (CHIK) virus is a member of the genus Alphavirus in the family TOGAVIRIDAE: Serologically, it is most closely related to o'nyong-nyong (ONN) virus and is a member of the Semliki Forest antigenic complex. CHIK virus is believed to be enzootic throughout much of Africa and historical evidence indicates that it spread to other parts of the world from this origin. Strains from Africa and Asia are reported to differ biologically, indicating that distinct lineages may exist. To examine the relatedness of CHIK and ONN viruses using genetic data, we conducted phylogenetic studies on isolates obtained throughout Africa and Southeast Asia. Analyses revealed that ONN virus is indeed distinct from CHIK viruses, and these viruses probably diverged thousands of years ago. Two distinct CHIK virus lineages were delineated, one containing all isolates from western Africa and the second comprising all southern and East African strains, as well as isolates from Asia. Phylogenetic trees corroborated historical evidence that CHIK virus originated in Africa and subsequently was introduced into Asia. Within the eastern Africa and southern Africa/Asia lineage, Asian strains grouped together in a genotype distinct from the African groups. These different geographical genotypes exhibit differences in their transmission cycles: in Asia, the virus appears to be maintained in an urban cycle with Aedes aegypti mosquito vectors, while CHIK virus transmission in Africa involves a sylvatic cycle, primarily with AE: furcifer and AE: africanus mosquitoes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-1317
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
471-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10644846-Aedes, pubmed-meshheading:10644846-Africa, pubmed-meshheading:10644846-Alphavirus, pubmed-meshheading:10644846-Alphavirus Infections, pubmed-meshheading:10644846-Animals, pubmed-meshheading:10644846-Antibodies, Viral, pubmed-meshheading:10644846-Antigens, Viral, pubmed-meshheading:10644846-Asia, Southeastern, pubmed-meshheading:10644846-Base Sequence, pubmed-meshheading:10644846-Chikungunya virus, pubmed-meshheading:10644846-Cricetinae, pubmed-meshheading:10644846-DNA Primers, pubmed-meshheading:10644846-Evolution, Molecular, pubmed-meshheading:10644846-Humans, pubmed-meshheading:10644846-Insect Vectors, pubmed-meshheading:10644846-Mice, pubmed-meshheading:10644846-Molecular Sequence Data, pubmed-meshheading:10644846-Phylogeny, pubmed-meshheading:10644846-Serotyping, pubmed-meshheading:10644846-Time Factors
pubmed:year
2000
pubmed:articleTitle
Re-emergence of Chikungunya and O'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships.
pubmed:affiliation
Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, USA. ampowers@culex.utmb.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't