| pubmed-article:10644655 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10644655 | lifeskim:mentions | umls-concept:C0015385 | lld:lifeskim |
| pubmed-article:10644655 | lifeskim:mentions | umls-concept:C1705480 | lld:lifeskim |
| pubmed-article:10644655 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10644655 | lifeskim:mentions | umls-concept:C0205386 | lld:lifeskim |
| pubmed-article:10644655 | lifeskim:mentions | umls-concept:C2346714 | lld:lifeskim |
| pubmed-article:10644655 | lifeskim:mentions | umls-concept:C0288406 | lld:lifeskim |
| pubmed-article:10644655 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10644655 | pubmed:dateCreated | 2000-3-31 | lld:pubmed |
| pubmed-article:10644655 | pubmed:abstractText | The renal urea transporter gene (UT-A) produces different transcripts in the inner medullary collecting ducts (UT-A1) and thin descending limbs of Henle's loop (UT-A2), coding for distinct proteins. Peptide-directed rabbit polyclonal antibodies were used to identify the UT-A2 protein in renal medulla of mouse and rat. In the inner stripe of outer medulla, an antibody directed to the COOH terminus of UT-A recognized a membrane protein of 55 kDa. The abundance of this 55-kDa protein was strongly increased in response to chronic infusion of the vasopressin analog 1-deamino-[8-D-arginine]vasopressin (DDAVP) in Brattleboro rats, consistent with previous evidence that UT-A2 mRNA abundance is markedly increased. Immunofluorescence labeling with the COOH-terminal antibody in Brattleboro rats revealed labeling in the lower portion of descending limbs from short-looped nephrons (in the aquaporin-1-negative portion of this segment). This UT-A labeling was increased in response to DDAVP. Increased labeling was also seen in descending limbs of long-looped nephrons in the base of the inner medulla. These results indicate that UT-A2 is expressed as a 55-kDa protein in portions of the thin descending limbs of Henle's loop and that the abundance of this protein is strongly upregulated by vasopressin. | lld:pubmed |
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| pubmed-article:10644655 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10644655 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644655 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10644655 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10644655 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10644655 | pubmed:issn | 1931-857X | lld:pubmed |
| pubmed-article:10644655 | pubmed:author | pubmed-author:LiuJJ | lld:pubmed |
| pubmed-article:10644655 | pubmed:author | pubmed-author:LeeA JAJ | lld:pubmed |
| pubmed-article:10644655 | pubmed:author | pubmed-author:WebbG BGB | lld:pubmed |
| pubmed-article:10644655 | pubmed:author | pubmed-author:MitchellCC | lld:pubmed |
| pubmed-article:10644655 | pubmed:author | pubmed-author:KnepperM AMA | lld:pubmed |
| pubmed-article:10644655 | pubmed:author | pubmed-author:KimG HGH | lld:pubmed |
| pubmed-article:10644655 | pubmed:author | pubmed-author:TerrisJJ | lld:pubmed |
| pubmed-article:10644655 | pubmed:author | pubmed-author:EcelbargerC... | lld:pubmed |
| pubmed-article:10644655 | pubmed:author | pubmed-author:BradfordA DAD | lld:pubmed |
| pubmed-article:10644655 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10644655 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:10644655 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10644655 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10644655 | pubmed:pagination | F52-62 | lld:pubmed |
| pubmed-article:10644655 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:10644655 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10644655 | pubmed:articleTitle | UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin. | lld:pubmed |
| pubmed-article:10644655 | pubmed:affiliation | Department of Physiology, Univ. of Maryland School of Medicine, Baltimore, MD 21201, USA. | lld:pubmed |
| pubmed-article:10644655 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10644655 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10644655 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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