Source:http://linkedlifedata.com/resource/pubmed/id/10644456
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2000-3-2
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| pubmed:databankReference | |
| pubmed:abstractText |
Protocadherins (Pcdhs) are members of the rapidly growing cadherin superfamily and are thought to be involved in cell-cell recognition in the central nervous system. Using human BH-Pcdh cDNA, we retrieved a homologous gene from the database. The new gene (Pcdh-X, HGMW-approved symbol PCDH11) was present on a genomic clone of human chromosome X (clone bWXD306), between two sequence tagged sites, sWXD1362 and 221. Pcdh-X therefore maps to the XY homology region in Xq21.3. The open reading frame consists of 1021 amino acids (aa) including seven cadherin repeats (EC1-7) in the extracellular domain. The Pcdh-X gene consists of at least three exons; the first exon encodes the 5'-untranslated region, EC1, and half of EC2, the second exon encodes the remainder of the Pcdh-Xa, and the third exon encodes the cytoplasmic tail of Pcdh-Xb and its 3'-untranslated region. The second exon has an alternative splice site that is used to produce two isoforms with different cytoplasmic tails of 10 (Pcdh-Xa) or 14 amino acids (Pcdh-Xb). Northern blot analysis revealed an approximately 6.0-kb transcript expressed in human and mouse fetal brain.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0888-7543
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
62
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
540-3
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10644456-Amino Acid Sequence,
pubmed-meshheading:10644456-Animals,
pubmed-meshheading:10644456-Blotting, Northern,
pubmed-meshheading:10644456-Brain,
pubmed-meshheading:10644456-Cadherins,
pubmed-meshheading:10644456-Chromosomes, Human, Pair 5,
pubmed-meshheading:10644456-Embryo, Mammalian,
pubmed-meshheading:10644456-Exons,
pubmed-meshheading:10644456-Fetus,
pubmed-meshheading:10644456-Humans,
pubmed-meshheading:10644456-Mice,
pubmed-meshheading:10644456-Molecular Sequence Data,
pubmed-meshheading:10644456-Multigene Family,
pubmed-meshheading:10644456-Physical Chromosome Mapping,
pubmed-meshheading:10644456-Sequence Analysis, DNA,
pubmed-meshheading:10644456-Sequence Homology, Amino Acid,
pubmed-meshheading:10644456-X Chromosome,
pubmed-meshheading:10644456-Y Chromosome
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Identification of a novel protocadherin gene (PCDH11) on the human XY homology region in Xq21.3.
|
| pubmed:affiliation |
Department of Virology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|