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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-3-28
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pubmed:abstractText |
To determine whether interleukin-10 (IL-10) could alter the development of grain dust-induced airway disease, we pretreated mice with either saline or IL-10 intravenously, exposed the mice to an inhalation challenge with corn dust extract (CDE), and measured inflammation and the development of airway hyperreactivity. Pretreatment with IL-10, in comparison to saline, reduced the concentration and percentage of polymorphonuclear cells in the lavage fluid 30 min after the inhalation challenge with CDE (P < 0. 05). In comparison to saline-treated mice, IL-10 did not significantly alter the degree of airway hyperreactivity 30 min after the exposure to CDE. IL-10-treated mice lavaged 18 h after challenge with CDE also exhibited a lower percentage of polymorphonuclear cells in the lavage fluid (P < 0.05) and had significantly less airway hyperreactivity than did mice pretreated with the saline placebo (P < 0.05). These findings indicate that exogenous IL-10 is effective in reducing airway inflammation and airway hyperreactivity due to the inhalation of CDE.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
8750-7587
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10642378-Animals,
pubmed-meshheading:10642378-Anti-Inflammatory Agents,
pubmed-meshheading:10642378-Bronchial Hyperreactivity,
pubmed-meshheading:10642378-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:10642378-Dust,
pubmed-meshheading:10642378-Inflammation,
pubmed-meshheading:10642378-Interleukin-10,
pubmed-meshheading:10642378-Lipopolysaccharides,
pubmed-meshheading:10642378-Lung,
pubmed-meshheading:10642378-Lung Diseases, Obstructive,
pubmed-meshheading:10642378-Male,
pubmed-meshheading:10642378-Methacholine Chloride,
pubmed-meshheading:10642378-Mice,
pubmed-meshheading:10642378-Mice, Inbred C57BL,
pubmed-meshheading:10642378-Monokines,
pubmed-meshheading:10642378-Neutrophil Infiltration,
pubmed-meshheading:10642378-RNA, Messenger,
pubmed-meshheading:10642378-Respiratory Tract Diseases,
pubmed-meshheading:10642378-Zea mays
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pubmed:year |
2000
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pubmed:articleTitle |
IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity.
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pubmed:affiliation |
Pulmonary, Critical Care, and Occupational Medicine Division, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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