Linked Life Data

10641561

Source:http://linkedlifedata.com/resource/pubmed/id/10641561

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-1-28
pubmed:abstractText
Genetic studies of atopy-associated traits require unambiguous phenotypes to avoid both type 1 and 2 errors. The German Multicenter Allergy Study has provided a birth cohort with longitudinally well defined and stable phenotypes. We summarize data on candidate gene studies on chromosomes 12q, 5q, and 13q using high total IgE and atopic dermatitis (AD) as the most common atopy associated phenotypes in early childhood. We also present data on a functional RANTES promoter polymorphism that we recently identified. A significantly higher frequency of the mutant allele was seen in individuals of African descent compared to Caucasian subjects. In addition, an association of the polymorphism with AD could be demonstrated in the MAS cohort. Although the statistical approaches are limited, the MAS cohort has provided a valuable population for candidate gene studies in atopy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0954-7894
pubmed:author
pubmed:issnType
Print
pubmed:volume
29 Suppl 4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Genetic markers of atopy in infancy: results from the German Multicenter Allergy Study.
pubmed:affiliation
Johns Hopkins Allergy and Asthma Center, Division of Clinical Immunology, Baltimore, Maryland, USA.
pubmed:publicationType
Journal Article, Multicenter Study