| pubmed-article:10640774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10640774 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:10640774 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10640774 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:10640774 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:10640774 | lifeskim:mentions | umls-concept:C0332448 | lld:lifeskim |
| pubmed-article:10640774 | lifeskim:mentions | umls-concept:C1548437 | lld:lifeskim |
| pubmed-article:10640774 | lifeskim:mentions | umls-concept:C0522536 | lld:lifeskim |
| pubmed-article:10640774 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:10640774 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:10640774 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:10640774 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10640774 | pubmed:dateCreated | 2000-2-24 | lld:pubmed |
| pubmed-article:10640774 | pubmed:abstractText | Chronic rejection represents a major cause of long-term kidney graft loss. T cells that are predominant in long-term rejected kidney allografts (35 +/- 10% of area infiltrate) may thus be instrumental in this phenomenon, which is likely to be dependent on the indirect pathway of allorecognition only. We have analyzed the variations in T cell repertoire usage of the V beta chain at the complementary determining region 3 (CDR3) level in 18 human kidney grafts lost due to chronic rejection. We observed a strongly biased intragraft TCR V beta usage for the majority of V beta families and also a very high percentage (55%) of V beta families exhibiting common and oligoclonal V beta-C beta rearrangements in the grafts of patients with chronic rejection associated with superimposed histologically acute lesions. Furthermore, V beta 8 and V beta 23 families exhibited common and oligoclonal V beta-J beta rearrangements in 4 of 18 patients (22%). Several CDR3 amino acid sequences were found for the common and oligoclonal V beta 8-J beta 1.4 rearrangement. Quantitative PCR showed that biased V beta transcripts were also overexpressed in chronically rejected kidneys with superimposed acute lesions. In contrast, T lymphocytes infiltrating rejected allografts with chronic rejection only showed an unaltered Gaussian-type CDR3 length distribution. This pattern suggests that late graft failure associated with histological lesions restricted to Banff-defined chronic rejection does not involve T cell-mediated injury. Thus, our observation suggests that a limited number of determinants stimulates the recipient immune system in long-term allograft failure. The possibility of a local response against viral or parenchymatous cell-derived determinants is discussed. | lld:pubmed |
| pubmed-article:10640774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10640774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640774 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10640774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10640774 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10640774 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10640774 | pubmed:author | pubmed-author:GuilleyHH | lld:pubmed |
| pubmed-article:10640774 | pubmed:author | pubmed-author:SoulillouJ... | lld:pubmed |
| pubmed-article:10640774 | pubmed:author | pubmed-author:MoreauAA | lld:pubmed |
| pubmed-article:10640774 | pubmed:author | pubmed-author:GagniGG | lld:pubmed |
| pubmed-article:10640774 | pubmed:author | pubmed-author:BignonJ DJD | lld:pubmed |
| pubmed-article:10640774 | pubmed:author | pubmed-author:BrouardSS | lld:pubmed |
| pubmed-article:10640774 | pubmed:author | pubmed-author:GiralMM | lld:pubmed |
| pubmed-article:10640774 | pubmed:author | pubmed-author:CuturiM CMC | lld:pubmed |
| pubmed-article:10640774 | pubmed:author | pubmed-author:ImbertB MBM | lld:pubmed |
| pubmed-article:10640774 | pubmed:author | pubmed-author:SebilleFF | lld:pubmed |
| pubmed-article:10640774 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10640774 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10640774 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:10640774 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10640774 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10640774 | pubmed:pagination | 1553-63 | lld:pubmed |
| pubmed-article:10640774 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10640774 | pubmed:meshHeading | pubmed-meshheading:10640774... | lld:pubmed |
| pubmed-article:10640774 | pubmed:meshHeading | pubmed-meshheading:10640774... | lld:pubmed |
| pubmed-article:10640774 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10640774 | pubmed:articleTitle | Highly altered V beta repertoire of T cells infiltrating long-term rejected kidney allografts. | lld:pubmed |
| pubmed-article:10640774 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale, Unité 437, "Immunointervention dans les Allo et Xénotransplantations" Nantes, France. | lld:pubmed |
| pubmed-article:10640774 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10640774 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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