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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-2-10
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pubmed:abstractText |
A selective mutation, an arginine-to-serine substitution in codon 249, of the p53 gene has been identified as a "hotspot" mutation in hepatocellular carcinoma (HCC). This mutation occurs in populations that are exposed to aflatoxins and have a high prevalence of hepatitis B virus carriers. We evaluated whether this mutation could be detected in cell-free DNA isolated from the plasma of subjects from The Gambia to detect this mutation that is strongly associated with HCC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
148-53
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10639517-Adult,
pubmed-meshheading:10639517-Aflatoxins,
pubmed-meshheading:10639517-African Continental Ancestry Group,
pubmed-meshheading:10639517-Aged,
pubmed-meshheading:10639517-Aged, 80 and over,
pubmed-meshheading:10639517-Arginine,
pubmed-meshheading:10639517-Carcinoma, Hepatocellular,
pubmed-meshheading:10639517-Case-Control Studies,
pubmed-meshheading:10639517-DNA, Neoplasm,
pubmed-meshheading:10639517-Endonucleases,
pubmed-meshheading:10639517-European Continental Ancestry Group,
pubmed-meshheading:10639517-Female,
pubmed-meshheading:10639517-France,
pubmed-meshheading:10639517-Gambia,
pubmed-meshheading:10639517-Hepatitis B,
pubmed-meshheading:10639517-Humans,
pubmed-meshheading:10639517-Liver Cirrhosis,
pubmed-meshheading:10639517-Liver Neoplasms,
pubmed-meshheading:10639517-Male,
pubmed-meshheading:10639517-Middle Aged,
pubmed-meshheading:10639517-Molecular Epidemiology,
pubmed-meshheading:10639517-Mutation,
pubmed-meshheading:10639517-Odds Ratio,
pubmed-meshheading:10639517-Polymerase Chain Reaction,
pubmed-meshheading:10639517-Prevalence,
pubmed-meshheading:10639517-Prospective Studies,
pubmed-meshheading:10639517-Sequence Analysis, DNA,
pubmed-meshheading:10639517-Serine,
pubmed-meshheading:10639517-Tumor Suppressor Protein p53
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pubmed:year |
2000
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pubmed:articleTitle |
Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia.
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pubmed:affiliation |
International Agency for Research on Cancer, Banjul, The Gambia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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