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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-2-10
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pubmed:abstractText |
Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors recur frequently because of the development of metastases that are resistant to tamoxifen. We have previously shown that mutagenesis of human estrogen-dependent ZR-75-1 breast cancer cells by insertion of a defective retrovirus genome caused the cells to become antiestrogen resistant. In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Hormonal,
http://linkedlifedata.com/resource/pubmed/chemical/BCAR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Crk-Associated Substrate Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor Modulators,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma-Like Protein p130,
http://linkedlifedata.com/resource/pubmed/chemical/Tamoxifen
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10639512-Amino Acid Sequence,
pubmed-meshheading:10639512-Antineoplastic Agents, Hormonal,
pubmed-meshheading:10639512-Breast Neoplasms,
pubmed-meshheading:10639512-Cell Fusion,
pubmed-meshheading:10639512-Crk-Associated Substrate Protein,
pubmed-meshheading:10639512-Drug Resistance, Neoplasm,
pubmed-meshheading:10639512-Estrogen Receptor Modulators,
pubmed-meshheading:10639512-Female,
pubmed-meshheading:10639512-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10639512-Genes, BRCA1,
pubmed-meshheading:10639512-Humans,
pubmed-meshheading:10639512-Molecular Sequence Data,
pubmed-meshheading:10639512-Neoplasms, Hormone-Dependent,
pubmed-meshheading:10639512-Phenotype,
pubmed-meshheading:10639512-Phosphoproteins,
pubmed-meshheading:10639512-Proteins,
pubmed-meshheading:10639512-Receptors, Estrogen,
pubmed-meshheading:10639512-Retinoblastoma-Like Protein p130,
pubmed-meshheading:10639512-Sequence Analysis, DNA,
pubmed-meshheading:10639512-Tamoxifen,
pubmed-meshheading:10639512-Time Factors,
pubmed-meshheading:10639512-Transfection,
pubmed-meshheading:10639512-Tumor Cells, Cultured,
pubmed-meshheading:10639512-Up-Regulation
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pubmed:year |
2000
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pubmed:articleTitle |
BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
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pubmed:affiliation |
Department of Pathology/Division of Molecular Biology, Josephine Nefkens Institute, University Hospital Rotterdam, The Netherlands. brinkman@bidh.azr.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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