Linked Life Data

10638522

Source:http://linkedlifedata.com/resource/pubmed/id/10638522

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-2-8
pubmed:abstractText
Molecular analysis of several gerontogenes of Caenorhabditis elegans has led to the discovery of at least two life span-controlling pathways. An insulin-like signaling cascade consisting of proteins encoded by the genes daf-2, age-1, akt-1, akt-2, daf-16 and daf-18 regulates dauer diapause, reproduction, and longevity. This pathway regulates all three processes systemically. daf-12 interacts with it, affecting dauer diapause and longevity. Life span extension mediated by this pathway probably results from the activation of an enhanced life-maintenance program, which is normally operative during dauer diapause. A different mechanism is specified by the clock genes clk-1, clk-2, clk-3 and gro-1, which regulate metabolic activity and the pace of many temporal processes including longevity. There is some controversy as to whether the life span extension observed in these mutants requires the activity of daf-16. All known gerontogenes appear to confer resistance to environmental stress, usually multiple stress factors, including oxidative stress, high temperature, and exposure to ultraviolet radiation. Caloric restriction extends longevity substantially, and may act by activating the enhanced life-maintenance program.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0197-4580
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
487-502
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Mechanisms of life span determination in Caenorhabditis elegans.
pubmed:affiliation
Department of Biology, University of Ghent, Belgium. Jacques.Vanfleteren@rug.ac.be
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't