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rdf:type |
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lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0039082,
umls-concept:C0039194,
umls-concept:C0205245,
umls-concept:C0439097,
umls-concept:C0871161,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1705241,
umls-concept:C1823153,
umls-concept:C2349976
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pubmed:issue |
2
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pubmed:dateCreated |
2000-1-27
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pubmed:abstractText |
In this study we have examined the phenotypic and functional properties of circulating gamma delta T cells in patients with Guillain Barre syndrome (GBS), in normal healthy controls, and in patients with active multiple sclerosis (MS). Cells expressing the Vdelta2 T cell receptor showed elevated expression of the C-lectin receptor NKRP1A in both GBS and MS, suggestive of an activated state. However, in patients with GBS these cells failed to respond to pyrenil-pyrophosphate derivatives and Vdelta2 + T cell clones derived from these patients released lower levels of IFNgamma than Vdelta2 + clones derived from controls and MS patients. In contrast, in patients with GBS the Vdelta1 + subset was expanded, showed elevated expression of NKRPIA and Vdelta1 + clones derived from these patients secreted high levels of IL-4. Our findings of expanded NKRP-1A +, IL-4-producing Vdelta1 T cells in the GBS patients suggests the possibility that these cells are activated by the recognition of non-protein antigens in an MHC-unrestricted manner and contribute to the humoral response to glycolipids that is a hallmark of this disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/KLRB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0165-5728
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pubmed:author |
pubmed-author:BachSS,
pubmed-author:BattistiniLL,
pubmed-author:BonettiBB,
pubmed-author:BorsellinoGG,
pubmed-author:BrosnanC FCF,
pubmed-author:CiprianiBB,
pubmed-author:GalganiSS,
pubmed-author:LuchettiSS,
pubmed-author:MancinoGG,
pubmed-author:PlacidoRR,
pubmed-author:PocciaFF,
pubmed-author:TramontiDD
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-207
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10636489-Adult,
pubmed-meshheading:10636489-Antigens, Surface,
pubmed-meshheading:10636489-Blood Cells,
pubmed-meshheading:10636489-Cytokines,
pubmed-meshheading:10636489-Guillain-Barre Syndrome,
pubmed-meshheading:10636489-Humans,
pubmed-meshheading:10636489-Killer Cells, Natural,
pubmed-meshheading:10636489-Lectins, C-Type,
pubmed-meshheading:10636489-Ligands,
pubmed-meshheading:10636489-Multiple Sclerosis,
pubmed-meshheading:10636489-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:10636489-Phenotype,
pubmed-meshheading:10636489-Phosphorylation,
pubmed-meshheading:10636489-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:10636489-Receptors, Immunologic,
pubmed-meshheading:10636489-Receptors, Natural Killer Cell,
pubmed-meshheading:10636489-Reference Values,
pubmed-meshheading:10636489-T-Lymphocytes
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pubmed:year |
2000
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pubmed:articleTitle |
Phenotypic and functional properties of gamma delta T cells from patients with Guillain Barré syndrome.
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pubmed:affiliation |
Laboratory of Neuroimmunology, IRCCS Santa Lucia, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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