rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-2-28
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pubmed:abstractText |
The chemical synthesis of the zwitterionic disaccharide 2 is described that corresponds to the repeating unit of the O-specific polysaccharide (1) of the gram-negative human pathogen Shigella sonnei. Passive hemolysis inhibition tests using a hyperimmune rabbit serum raised against S. sonnei showed that the serologic activity of the disaccharide 2 is nearly 2- to 3-fold higher than those of its component monosaccharides. NMR data of 2 are in support of the proposed structure of the O-specific polysaccharide.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Jan
|
pubmed:issn |
0960-894X
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
3
|
pubmed:volume |
10
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
19-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10636234-Animals,
pubmed-meshheading:10636234-Complement System Proteins,
pubmed-meshheading:10636234-Disaccharides,
pubmed-meshheading:10636234-Erythrocytes,
pubmed-meshheading:10636234-Galactose,
pubmed-meshheading:10636234-Guinea Pigs,
pubmed-meshheading:10636234-Hemolysis,
pubmed-meshheading:10636234-Lipopolysaccharides,
pubmed-meshheading:10636234-Monosaccharides,
pubmed-meshheading:10636234-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:10636234-O Antigens,
pubmed-meshheading:10636234-Rabbits,
pubmed-meshheading:10636234-Sheep,
pubmed-meshheading:10636234-Shigella sonnei,
pubmed-meshheading:10636234-Stereoisomerism,
pubmed-meshheading:10636234-Uronic Acids
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pubmed:year |
2000
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pubmed:articleTitle |
Synthesis of the repeating unit of the O-specific polysaccharide of Shigella sonnei and quantitation of its serologic activity.
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pubmed:affiliation |
Research Group for Carbohydrates of the Hungarian Academy of Sciences and Institute of Biochemistry, Lajos Kossuth University, Debrecen.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|