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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-2-28
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pubmed:abstractText |
Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led to a potency enhancement of greater than 200-fold compared to human growth hormone secretagogue affinity of a screening lead 4.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BakshiR KRK,
pubmed-author:BirzinE TET,
pubmed-author:BlakeAA,
pubmed-author:ChanW WWW,
pubmed-author:ChenM HMH,
pubmed-author:FeighnerS DSD,
pubmed-author:GaySS,
pubmed-author:HowardA DAD,
pubmed-author:LocciFF,
pubmed-author:NargundR PRP,
pubmed-author:ParmarR MRM,
pubmed-author:PatchettA AAA,
pubmed-author:PongS SSS,
pubmed-author:RohrerS PSP,
pubmed-author:SchaefferJ MJM,
pubmed-author:SmithR GRG,
pubmed-author:YuJJ
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10636230-Animals,
pubmed-meshheading:10636230-Binding Sites,
pubmed-meshheading:10636230-Drug Design,
pubmed-meshheading:10636230-Human Growth Hormone,
pubmed-meshheading:10636230-Humans,
pubmed-meshheading:10636230-Inhibitory Concentration 50,
pubmed-meshheading:10636230-Kinetics,
pubmed-meshheading:10636230-Models, Molecular,
pubmed-meshheading:10636230-Quinazolines,
pubmed-meshheading:10636230-Rats,
pubmed-meshheading:10636230-Receptors, Cell Surface,
pubmed-meshheading:10636230-Receptors, G-Protein-Coupled,
pubmed-meshheading:10636230-Receptors, Ghrelin,
pubmed-meshheading:10636230-Secretory Rate,
pubmed-meshheading:10636230-Structure-Activity Relationship
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pubmed:year |
2000
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pubmed:articleTitle |
Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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