Linked Life Data

10635036

Source:http://linkedlifedata.com/resource/pubmed/id/10635036

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-1-28
pubmed:abstractText
Neurotrophins are target-derived soluble factors required for neuronal survival. Nerve growth factor (NGF) the founding member of the neurotrophin family, binds to two types of receptors: Trk tyrosine kinase and the p75 neurotrophin receptor, which belongs to the Fas-tumor necrosis factor (TNF) receptor superfamily. Binding of neurotrophins to Trk receptor tyrosine kinases initiate signaling cascades that promote cell survival sand differentiation. In contrast, p75 NGFR has been shown to modulate the susceptibility to death of selective cellular populations--including differentiated rat oligodendrocytes--in specific conditions. Notably, NGF effect on viability was only observed in fully differentiated oligodendrocytes and not in oligodendrocyte progenitor cells. The effect of p75 activation on oligodendrocyte survival correlates with increased activity of the stress related kinase JNK-1 and cleavage of specific caspases. Indeed, activation of additional stress pathways or impairment of survival signals may be required for p75 mediated activation of cell death execution programs. Interestingly, co-expression of the TrkA receptor in the same cell type abolishes the JNK-1 mediated death signal and induces MAP kinase activity, resulting in cell survival. This suggests that glial cell survival results from a balance between positive and negative regulators modulated by selective signalling pathways by tyrosine kinases and cytokine receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
468
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-82
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Neurotrophins in cell survival/death decisions.
pubmed:affiliation
Skirball Institute, New York University Medical Center, New York 10016, USA.
pubmed:publicationType
Journal Article, Review