Source:http://linkedlifedata.com/resource/pubmed/id/10633492
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2000-1-28
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| pubmed:abstractText |
Acute administration of the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (1-10 mg/kg, i.p. 1 h before an elevated plus-maze test), to Spontaneously Hypertensive rats (SHRs), Lewis (LEW) rats, and Wistar-Kyoto (WKY) rats, i.e., rat strains differing for their emotionality, promoted anxiety, and/or hypoactivity, except in WKY rats. In the three strains, such a pretreatment increased central 5-HT levels and/or decreased 5-hydroxyindoleacetic acid levels. Hippocampal, but not midbrain or striatal, [3H]citalopram binding at 5-HT transporters was lower in WKY rats than in SHRs. However, neither [3H]5-HT reuptake kinetics nor the potencies of citalopram (1-1000 nM) to inhibit [3H]5-HT reuptake into hippocampal and striatal synaptosomes differed between strains. This was confirmed in vivo by means of microdialysis in the hippocampus of freely moving rats. Thus, although LEW rats displayed a 3-4 fold higher baseline level of extracellular 5-HT in the hippocampus, compared with SHRs and WKY rats, local perfusion with 1 microM citalopram promoted relative increases in extracellular 5-HT levels over baseline that were similar in all strains. Lastly, acute i.p. administration of 3.3 mg/kg citalopram (1 h beforehand) decreased to similar extents [3H]5-HT reuptake into hippocampal synaptosomes from SHRs and WKY rats. This study indicates that genetic differences in the behavioural responses to SSRIs may involve 5-HT transporter-independent mechanisms.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0893-133X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
64-76
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| pubmed:dateRevised |
2011-5-18
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| pubmed:meshHeading |
pubmed-meshheading:10633492-Animals,
pubmed-meshheading:10633492-Brain,
pubmed-meshheading:10633492-Citalopram,
pubmed-meshheading:10633492-Corpus Striatum,
pubmed-meshheading:10633492-Emotions,
pubmed-meshheading:10633492-Hippocampus,
pubmed-meshheading:10633492-Hydroxyindoleacetic Acid,
pubmed-meshheading:10633492-Male,
pubmed-meshheading:10633492-Maze Learning,
pubmed-meshheading:10633492-Microdialysis,
pubmed-meshheading:10633492-Organ Specificity,
pubmed-meshheading:10633492-Rats,
pubmed-meshheading:10633492-Rats, Inbred Lew,
pubmed-meshheading:10633492-Rats, Inbred SHR,
pubmed-meshheading:10633492-Rats, Inbred WKY,
pubmed-meshheading:10633492-Serotonin,
pubmed-meshheading:10633492-Serotonin Uptake Inhibitors,
pubmed-meshheading:10633492-Species Specificity
|
| pubmed:year |
2000
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| pubmed:articleTitle |
Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality.
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| pubmed:affiliation |
Laboratory of NeuroGénétique and Stress, INSERM U471, Bordeaux, France.
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| pubmed:publicationType |
Journal Article
|