Linked Life Data

10632892

Source:http://linkedlifedata.com/resource/pubmed/id/10632892

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-3-24
pubmed:abstractText
We have cloned the H1 histone gene (hhoA) of Aspergillus nidulans. This single-copy gene codes for a typical linker histone with one central globular domain. The open reading frame is interrupted by six introns. The position of the first intron is identical to that of introns found in some plant histones. An H1-GFP fusion shows exclusive nuclear localization, whereas chromosomal localization can be observed during condensation at mitosis. Surprisingly, the deletion of hhoA results in no obvious phenotype. The nucleosomal repeat length and susceptibility to micrococcal nuclease digestion of A. nidulans chromatin are unchanged in the deleted strain. The nucleosomal organization of a number of promoters, including in particular the strictly regulated niiA-niaD bidirectional promoter is not affected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0950-382X
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-33
pubmed:dateRevised
2007-8-9
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Deletion of the unique gene encoding a typical histone H1 has no apparent phenotype in Aspergillus nidulans.
pubmed:affiliation
Institut de Génétique et Microbiologie, Bâtiment 409, Université Paris-Sud, UMR 8621, 91405 Orsay Cedex, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't