Linked Life Data

10632527

Source:http://linkedlifedata.com/resource/pubmed/id/10632527

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2000-2-1
pubmed:abstractText
Following the surgical treatment of adult periodontitis, the epithelial regeneration of the periodontal attachment is non-physiological and thus unsatisfactory, if membranes or artificial bone material are not used. Re-epithelialization is based on the proliferation, migration, and differentiation of basal epithelial cells which are in contact with a wound matrix and whose molecular makeup differs from the extracellular matrix of intact regions. Interactions between basal epithelial cells and the extracellular matrix are mediated by special receptors on the cell surface which are known as integrins and belong to the family of cellular adhesion molecules (CAM). Various studies indicate that integrin-mediated interaction plays a decisive role in regulating the proliferation, migration, and differentiation of the epithelial cells. This review provides an overview of the in vivo and in vitro expression of integrins by epithelial cells and the interaction between integrins and extracellular matrix (ECM) in the case of a stationary epithelium and during wound healing. The regulation of these cell-cell and cell-matrix interactions may represent a method for inhibiting non-physiological epithelial regeneration on the molecular level.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-3492
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1511-22
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Role of interactions between integrins and extracellular matrix components in healthy epithelial tissue and establishment of a long junctional epithelium during periodontal wound healing: a review.
pubmed:affiliation
Clinic of Conservative & Preventive Dentistry and Periodontology, Technical University, Aachen, Germany.
pubmed:publicationType
Journal Article, Review