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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2000-2-3
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pubmed:abstractText |
We have investigated the immunomodulatory effects of arctigenin, a dibenzyl butyrolactone lignan compound, on tumour necrosis factor (TNF)-alpha and nitric oxide (NO) production, and lymphocyte proliferation. Arctigenin inhibited strongly TNF-alpha production by lipopolysaccharide-stimulated murine macrophage RAW264.7 and differentiated human macrophage U937 with IC50 values of 5.0 and 3.9 microM, respectively, without displaying cytotoxicity. The TNF-alpha inhibitory effect of arctigenin in lipopolysaccharide-triggered RAW264.7 cells was increased by co-treatment with several known TNF-alpha inhibitors. It also potently attenuated T and B cell proliferation stimulated by concanavalin A and lipopolysaccharide in a dose-dependent manner with IC50 values of 2.9 and 14.6 microM, respectively. In contrast, the compound showed a different pattern in lipopolysaccharide- and interferon (IFN)-gamma-induced NO production from RAW264.7 cells. Arctigenin inhibited NO release by IFN-gamma signal, whereas it significantly enhanced lipopolysaccharide-triggered NO production in RAW264.7 cells. The results suggested that arctigenin may regulate immune responses in activated macrophages and lymphocytes including TNF-alpha and NO production and lymphocyte proliferation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Coloring Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Endotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Furans,
http://linkedlifedata.com/resource/pubmed/chemical/Lignans,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/arctigenin,
http://linkedlifedata.com/resource/pubmed/chemical/endotoxin, Escherichia coli,
http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3573
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1267-73
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10632084-Adjuvants, Immunologic,
pubmed-meshheading:10632084-Animals,
pubmed-meshheading:10632084-B-Lymphocytes,
pubmed-meshheading:10632084-Cell Differentiation,
pubmed-meshheading:10632084-Cell Division,
pubmed-meshheading:10632084-Cell Survival,
pubmed-meshheading:10632084-Cells, Cultured,
pubmed-meshheading:10632084-Coloring Agents,
pubmed-meshheading:10632084-Endotoxins,
pubmed-meshheading:10632084-Escherichia coli,
pubmed-meshheading:10632084-Furans,
pubmed-meshheading:10632084-Lignans,
pubmed-meshheading:10632084-Lipopolysaccharides,
pubmed-meshheading:10632084-Male,
pubmed-meshheading:10632084-Mice,
pubmed-meshheading:10632084-Mice, Inbred BALB C,
pubmed-meshheading:10632084-Nitric Oxide,
pubmed-meshheading:10632084-Spleen,
pubmed-meshheading:10632084-T-Lymphocytes,
pubmed-meshheading:10632084-Tetrazolium Salts,
pubmed-meshheading:10632084-Thiazoles,
pubmed-meshheading:10632084-Tumor Necrosis Factor-alpha
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pubmed:year |
1999
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pubmed:articleTitle |
Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation.
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pubmed:affiliation |
Department of Immunopharmacology, R & D Center, Daewoong Pharmaceutical Co. Ltd, Sungnam, Korea. jae.cho@ucl.ac.uk
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pubmed:publicationType |
Journal Article
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