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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-2-7
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pubmed:databankReference |
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pubmed:abstractText |
The parapoxvirus orf virus encodes a novel soluble protein inhibitor of ovine granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2). The GM-CSF- and IL-2-inhibitory factor (GIF) gene was expressed as an intermediate-late viral gene in orf virus-infected cells. GIF formed homodimers and tetramers in solution, and it bound ovine GM-CSF with a K(d) of 369 pM and ovine IL-2 with a K(d) of 1.04 nM. GIF did not bind human GM-CSF or IL-2 in spite of the fact that orf virus is a human pathogen. GIF was detected in afferent lymph plasma draining the skin site of orf virus reinfection and was associated with reduced levels of lymph GM-CSF. GIF expression by orf virus indicates that GM-CSF and IL-2 are important in host antiviral immunity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-10233690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-1339315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-1369995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-1394428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-1533931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-1572550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-1651230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-1832774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-1949568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-2045793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-2151765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-2219722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-2258611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-2378601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-2475963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-3029950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-3727328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-462811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-6319750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-7421589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-7484461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-7545851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-7608155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-7609027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-7723661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-7758109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-7852384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-7888670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-7892272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-8091665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-8094759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-8254780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-8405235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-8425202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-8609492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-8717509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-8794016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-8910744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9014816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9112329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9123861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9151824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9151886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9162525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9325239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9365110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9557689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9640243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627542-9857983
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1313-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10627542-Humans,
pubmed-meshheading:10627542-Animals,
pubmed-meshheading:10627542-Lymph,
pubmed-meshheading:10627542-Cattle,
pubmed-meshheading:10627542-Sheep,
pubmed-meshheading:10627542-Cricetinae,
pubmed-meshheading:10627542-Ecthyma, Contagious,
pubmed-meshheading:10627542-Base Sequence,
pubmed-meshheading:10627542-Cells, Cultured
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