Linked Life Data

10627520

Source:http://linkedlifedata.com/resource/pubmed/id/10627520

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-2-7
pubmed:abstractText
Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed during latent Epstein-Barr virus (EBV) infections in human peripheral B cells. LMP2A blocks B-cell receptor (BCR) signal transduction in vitro by modulation of the Syk and Lyn protein tyrosine kinases. Five genetically unique LMP2A transgenic mouse lines (EmuLMP2A) with B-cell lineage expression of LMP2A were generated in this study to analyze the importance of LMP2A expression in vivo. These animals can be grouped into EmuLMP2A(BCR+) (TgB, Tg6, and TgC) and EmuLMP2A(BCR-) (Tg7 and TgE) lines based on B-cell phenotype. LMP2A expression in bone marrow cells of EmuLMP2A(BCR-) lines was associated with a bypass of normal B-lymphocyte developmental checkpoints inasmuch as immunoglobulin light-chain gene rearrangement occurred in the absence of complete immunoglobulin heavy-chain gene rearrangement. The resulting BCR-negative B cells were able to exit the bone marrow and colonize peripheral lymphoid organs. LMP2A expression in EmuLMP2A(BCR+) lines was not associated with altered B-cell development in a genetically wild-type background. When crossed into a recombinase activating null (RAG(-/-)) genetic background, LMP2A expression in either RAG(-/-) EmuLMP2A(BCR+) or RAG(-/-) EmuLMP2A(BCR-) animals was able to provide a survival signal to BCR-negative splenic B cells. Additionally, bone marrow cells from all EmuLMP2A animals were able to proliferate in response to interleukin-7-dependent developmental signals in vitro. These studies illustrate that LMP2A can provide a survival signal to BCR-negative B cells in two different groups of EmuLMP2A transgenic mice.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1313894, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1313931, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1316478, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1321296, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1328675, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1337032, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1377222, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1672968, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1710288, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1827140, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1850387, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1899373, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-1901381, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-2157888, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-2227421, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-2536113, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-2981780, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-3030940, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-7532548, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-7684459, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-7688784, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-7716544, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-7745723, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-7895172, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-7926785, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-7933121, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-8290598, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-8381153, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-8383224, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-8392630, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-8602530, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-8627812, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-8650582, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-8670812, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-8769480, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-8824794, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9120290, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9151869, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9188550, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9233622, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9269787, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9281504, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9323135, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9733815, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9746788, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9751773, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9768759, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9768760, http://linkedlifedata.com/resource/pubmed/commentcorrection/10627520-9847337
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1101-13
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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