Source:http://linkedlifedata.com/resource/pubmed/id/10627483
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2000-2-3
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| pubmed:abstractText |
PG27, an active fraction purified from an extract of a Chinese herb, Tripterygium wilfordii hook f, was used to prevent graft-versus-host disease (GVHD) in a murine model. Lethally irradiated BALB/c (H-2(d)) recipients of B10.D2 (H-2(d)) donor grafts were given daily intraperitoneal injections of PG27 (40 mg/kg per day) for the first 35 days after transplantation. Control mice were given daily injections of solvent vehicle (Ethanol and Cremophor EL). All the control recipients (15/15) died of GVHD within 90 days, but all the recipients given prophylactic treatment with PG27 (15/15) survived beyond 100 days without any signs of GVHD. Furthermore, the GVHD-free recipients were used as donors, and their bone marrow and spleen cells were transplanted into lethally irradiated normal BALB/c (same party) or lethally irradiated normal C3H (H-2(k), third party) mice. Although 10 of 10 same-party recipients survived more than 100 days without any signs of GVHD, 10 of 10 third-party C3H recipients died of GVHD within 40 days. Further studies of PG27 in the murine BCL1 leukemia/lymphoma model demonstrated that animals treated with PG27 partially retained the graft-versus-leukemia (GVL) effect of the graft without GVHD. These results suggest that treatment with PG27 induces host-specific tolerance and retains the GVL effect of allogeneic marrow grafts. (Blood. 2000;95:705-710)
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0006-4971
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
95
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
705-10
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10627483-Adoptive Transfer,
pubmed-meshheading:10627483-Animals,
pubmed-meshheading:10627483-Bone Marrow Transplantation,
pubmed-meshheading:10627483-Drugs, Chinese Herbal,
pubmed-meshheading:10627483-Graft vs Host Disease,
pubmed-meshheading:10627483-Immunosuppressive Agents,
pubmed-meshheading:10627483-Interleukin-1,
pubmed-meshheading:10627483-Leukemia, Experimental,
pubmed-meshheading:10627483-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:10627483-Lymphocyte Transfusion,
pubmed-meshheading:10627483-Mice,
pubmed-meshheading:10627483-Mice, Inbred BALB C,
pubmed-meshheading:10627483-Mice, Inbred C3H,
pubmed-meshheading:10627483-Mice, Inbred C57BL,
pubmed-meshheading:10627483-Mice, Inbred Strains,
pubmed-meshheading:10627483-Plant Extracts,
pubmed-meshheading:10627483-Polymerase Chain Reaction,
pubmed-meshheading:10627483-Spleen,
pubmed-meshheading:10627483-Transplantation, Homologous
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| pubmed:year |
2000
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| pubmed:articleTitle |
PG27, an extract of Tripterygium wilfordii hook f, induces antigen-specific tolerance in bone marrow transplantation in mice.
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| pubmed:affiliation |
Divisions of Hematology/Oncology and Immunology and Rheumatology, Stanford University, Stanford, CA.
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| pubmed:publicationType |
Journal Article
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