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rdf:type |
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lifeskim:mentions |
umls-concept:C0021311,
umls-concept:C0024267,
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0042776,
umls-concept:C0085358,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1517945,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
6
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pubmed:dateCreated |
2000-2-3
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pubmed:abstractText |
Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNgamma assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/T cell receptor peptide Vbeta8.1,
http://linkedlifedata.com/resource/pubmed/chemical/histocompatibility antigen H-2D(b)
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10626895-Animals,
pubmed-meshheading:10626895-Antigens, Viral,
pubmed-meshheading:10626895-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10626895-Cell Line, Transformed,
pubmed-meshheading:10626895-Dimerization,
pubmed-meshheading:10626895-Epitopes, T-Lymphocyte,
pubmed-meshheading:10626895-H-2 Antigens,
pubmed-meshheading:10626895-Immunodominant Epitopes,
pubmed-meshheading:10626895-Immunoglobulin G,
pubmed-meshheading:10626895-Immunologic Memory,
pubmed-meshheading:10626895-Interferon-gamma,
pubmed-meshheading:10626895-Lymphocytic choriomeningitis virus,
pubmed-meshheading:10626895-Major Histocompatibility Complex,
pubmed-meshheading:10626895-Mice,
pubmed-meshheading:10626895-Mice, Inbred BALB C,
pubmed-meshheading:10626895-Mice, Inbred C57BL,
pubmed-meshheading:10626895-Muromegalovirus,
pubmed-meshheading:10626895-Pichinde virus,
pubmed-meshheading:10626895-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10626895-Staining and Labeling,
pubmed-meshheading:10626895-Vaccinia virus,
pubmed-meshheading:10626895-Virus Diseases
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pubmed:year |
1999
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pubmed:articleTitle |
Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses.
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pubmed:affiliation |
Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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