| pubmed-article:10626786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C1522021 | lld:lifeskim |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C0883208 | lld:lifeskim |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:10626786 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:10626786 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:10626786 | pubmed:dateCreated | 2000-1-24 | lld:pubmed |
| pubmed-article:10626786 | pubmed:abstractText | Transcription factors p53 and nuclear factor kappaB (NF-kappaB) have been implicated in apoptosis induced by DNA-damaging agents, but the relationship between these two factors at the molecular level is largely unknown. We have isolated apoptosis-resistant mutant sublines from a radiosensitive mouse lymphoma 3SB cell line that undergoes p53-depen-dent apoptosis after X-ray irradiation, and we have analyzed the NF-kappaB activity. Two of these apoptosis-resistant sublines expressed mutant p53 protein and exhibited a defect in the induction of cyclin-dependent kinase inhibitor p21 after X-ray irradiation. A decrease in the DNA binding activity of NF-kappaB was observed in the parental 3SB cells after exposure to X-rays, whereas the same activity was unaffected by radiation in the two mutant sublines. A similar down-regulation of NF-kappaB activity by X-rays was observed in thymocytes derived from p53 wild-type and heterozygous mice, but not in thymocytes from p53 homozygous knock-out mice. These results suggest that NF-kappaB inactivation is p53 dependent and is required for X-ray-induced apoptosis in thymic lymphoma cells and normal thymocytes. | lld:pubmed |
| pubmed-article:10626786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10626786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10626786 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10626786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10626786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10626786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10626786 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10626786 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:10626786 | pubmed:author | pubmed-author:YamadaYY | lld:pubmed |
| pubmed-article:10626786 | pubmed:author | pubmed-author:YamamotoKK | lld:pubmed |
| pubmed-article:10626786 | pubmed:author | pubmed-author:KawaiHH | lld:pubmed |
| pubmed-article:10626786 | pubmed:author | pubmed-author:SuzukiFF | lld:pubmed |
| pubmed-article:10626786 | pubmed:author | pubmed-author:NiwaOO | lld:pubmed |
| pubmed-article:10626786 | pubmed:author | pubmed-author:TatsukaMM | lld:pubmed |
| pubmed-article:10626786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10626786 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10626786 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:10626786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10626786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10626786 | pubmed:pagination | 6038-41 | lld:pubmed |
| pubmed-article:10626786 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10626786 | pubmed:meshHeading | pubmed-meshheading:10626786... | lld:pubmed |
| pubmed-article:10626786 | pubmed:meshHeading | pubmed-meshheading:10626786... | lld:pubmed |
| pubmed-article:10626786 | pubmed:meshHeading | pubmed-meshheading:10626786... | lld:pubmed |
| pubmed-article:10626786 | pubmed:meshHeading | pubmed-meshheading:10626786... | lld:pubmed |
| pubmed-article:10626786 | pubmed:meshHeading | pubmed-meshheading:10626786... | lld:pubmed |
| pubmed-article:10626786 | pubmed:meshHeading | pubmed-meshheading:10626786... | lld:pubmed |
| pubmed-article:10626786 | pubmed:meshHeading | pubmed-meshheading:10626786... | lld:pubmed |
| pubmed-article:10626786 | pubmed:meshHeading | pubmed-meshheading:10626786... | lld:pubmed |
| pubmed-article:10626786 | pubmed:meshHeading | pubmed-meshheading:10626786... | lld:pubmed |
| pubmed-article:10626786 | pubmed:meshHeading | pubmed-meshheading:10626786... | lld:pubmed |
| pubmed-article:10626786 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10626786 | pubmed:articleTitle | Down-regulation of nuclear factor kappaB is required for p53-dependent apoptosis in X-ray-irradiated mouse lymphoma cells and thymocytes. | lld:pubmed |
| pubmed-article:10626786 | pubmed:affiliation | Department of Regulatory Radiobiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan. | lld:pubmed |
| pubmed-article:10626786 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10626786 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10626786 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10626786 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10626786 | lld:pubmed |
