Linked Life Data

10626297

Source:http://linkedlifedata.com/resource/pubmed/id/10626297

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-1-31
pubmed:abstractText
The many events of meiotic prophase can now be viewed as a series of specialized incidents that are monitored by meiotic checkpoints, some of which are similar to their mitotic counterparts, and some of which are probably unique to meiosis. This shift in perspective means that meiotic sterility in mammals must be reexamined and viewed as the result of errors subject to meiotic checkpoint controls. Like their mitotic counterparts, the meiotic checkpoints detect defects and halt normal progression until these mistakes can be repaired. Some of these checkpoints utilize mitotic checkpoint proteins, others may involve meiotic-specific proteins, or splice forms. If repair is impossible, the checkpoints then either trigger immediate apoptosis or cause an arrest of meiotic progression followed by eventual cell death. If a sufficient number of spermatocytes are involved, either alternative results in sterility. Identification of these meiotic checkpoints and delineation of the signal transduction cascades involved has only just begun. While yeast, or other model organisms, may provide clues to some of these pathways, others appears to have arisen during vertebrate evolution. The study of mammalian meiosis has entered a new era and the foundations are being laid for a growing understanding of the many problems that may contribute to sterility.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0080-1844
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-73
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
An integration of old and new perspectives of mammalian meiotic sterility.
pubmed:affiliation
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review