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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-1-27
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pubmed:databankReference |
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pubmed:abstractText |
Rapid conduction in myelinated axons depends on the generation of specialized subcellular domains to which different sets of ion channels are localized. Here, we describe the identification of Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), and show that this neurexin-like protein and the closely related molecule Caspr/Paranodin demarcate distinct subdomains in myelinated axons. While contactin-associated protein (Caspr) is present at the paranodal junctions, Caspr2 is precisely colocalized with Shaker-like K+ channels in the juxtaparanodal region. We further show that Caspr2 specifically associates with Kv1.1, Kv1.2, and their Kvbeta2 subunit. This association involves the C-terminal sequence of Caspr2, which contains a putative PDZ binding site. These results suggest a role for Caspr family members in the local differentiation of the axon into distinct functional subdomains.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1037-47
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10624965-Amino Acid Sequence,
pubmed-meshheading:10624965-Animals,
pubmed-meshheading:10624965-Axons,
pubmed-meshheading:10624965-Blotting, Northern,
pubmed-meshheading:10624965-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:10624965-Humans,
pubmed-meshheading:10624965-Immunohistochemistry,
pubmed-meshheading:10624965-Kv1.1 Potassium Channel,
pubmed-meshheading:10624965-Membrane Proteins,
pubmed-meshheading:10624965-Mice,
pubmed-meshheading:10624965-Microscopy, Electron,
pubmed-meshheading:10624965-Molecular Sequence Data,
pubmed-meshheading:10624965-Nerve Fibers, Myelinated,
pubmed-meshheading:10624965-Nerve Tissue Proteins,
pubmed-meshheading:10624965-Nervous System,
pubmed-meshheading:10624965-Potassium Channels,
pubmed-meshheading:10624965-Potassium Channels, Voltage-Gated,
pubmed-meshheading:10624965-Precipitin Tests,
pubmed-meshheading:10624965-Rats
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pubmed:year |
1999
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pubmed:articleTitle |
Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.
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pubmed:affiliation |
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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