Source:http://linkedlifedata.com/resource/pubmed/id/10624765
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2000-2-4
|
| pubmed:abstractText |
The recently reported increase in seroprevalence of Helicobacter pylori, the causative pathogen in peptic ulceration, in bronchiectasis is unexplained. Therefore, the association of antibodies directed against cytotoxin-associated gene A(CagA), whose expression indicates virulence of H. pylori, and upper gastrointestinal symptoms in patients with stable bronchiectasis and healthy volunteers evaluated. One hundred patients (mean +/- SD age 55.1+/-16.7 yrs) and 94 healthy asymptomatic subjects (54.6+/-7.6 yrs) underwent clinical and physiological assessment and serum levels of anti-H. pylori CagA were determined using standard clinical and enzyme-linked immunosorbent assay techniques. Samples were positive for anti-H. pylori CagA in 11.7% of controls and 24% of bronchiectatic subjects (p = 0.03). There was, however, no association between serum H. pylori CagA immunoglobulin G level and forced expiratory volume in one second (FEV1), forced vital capacity (FVC), sputum volume, respiratory symptoms or upper respiratory gastrointestinal symptoms (p>0.05). Patients who suffered from acid regurgitation or upper abdominal distension had significantly lower FEV1 and FVC (as a percentage of the predicted value) compared to their counterparts. The results of anticytotoxin-associated gene A measurements in this study contrasted with the previous finding that anti-Helicobacter pylori immunoglobulin G correlated with sputum volume. These findings, therefore, suggest that Helicobacter pylori, should it have a pathogenic role in bronchiectasis, could act via noncytotoxin-associated gene A-mediated mechanisms, and, in this context, gastro-oesophageal reflux might be of importance in bronchiectasis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0903-1936
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1345-50
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10624765-Adult,
pubmed-meshheading:10624765-Aged,
pubmed-meshheading:10624765-Antigens, Bacterial,
pubmed-meshheading:10624765-Bacterial Proteins,
pubmed-meshheading:10624765-Bronchiectasis,
pubmed-meshheading:10624765-Chi-Square Distribution,
pubmed-meshheading:10624765-Cohort Studies,
pubmed-meshheading:10624765-Female,
pubmed-meshheading:10624765-Gastrointestinal Diseases,
pubmed-meshheading:10624765-Genes, Bacterial,
pubmed-meshheading:10624765-Helicobacter Infections,
pubmed-meshheading:10624765-Helicobacter pylori,
pubmed-meshheading:10624765-Humans,
pubmed-meshheading:10624765-Male,
pubmed-meshheading:10624765-Middle Aged,
pubmed-meshheading:10624765-Reference Values,
pubmed-meshheading:10624765-Respiratory Function Tests,
pubmed-meshheading:10624765-Statistics, Nonparametric
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Helicobacter pylori and upper gastrointestinal symptoms in bronchiectasis.
|
| pubmed:affiliation |
University Dept of Medicine, The University of Hong Kong, Queen Mary Hospital, SAR.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|