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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-2-10
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pubmed:abstractText |
CD4+ T cells are important for resistance to infection with Salmonella typhimurium. However, the Ag specificity of this T cell response is unknown. Here, we demonstrate that a significant fraction of Salmonella-specific CD4+ T cells respond to the flagellar filament protein, FliC, and that this Ag has the capacity to protect naive mice from lethal Salmonella infection. To characterize this Ag-specific response further, we generated FliC-specific CD4+ T cell clones from mice that had resolved infection with an attenuated strain of Salmonella. These clones were found to respond to an epitope from a constant region of FliC, enabling them to cross-react with flagellar proteins expressed by a number of distinct Salmonella serovars.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Flagellin,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Constant Regions,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
986-93
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10623848-Amino Acid Sequence,
pubmed-meshheading:10623848-Animals,
pubmed-meshheading:10623848-Antigens,
pubmed-meshheading:10623848-Antigens, CD4,
pubmed-meshheading:10623848-Antigens, Surface,
pubmed-meshheading:10623848-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10623848-Cell Line,
pubmed-meshheading:10623848-Clone Cells,
pubmed-meshheading:10623848-Epitopes, T-Lymphocyte,
pubmed-meshheading:10623848-Female,
pubmed-meshheading:10623848-Flagellin,
pubmed-meshheading:10623848-Immunodominant Epitopes,
pubmed-meshheading:10623848-Immunoglobulin Constant Regions,
pubmed-meshheading:10623848-Lectins, C-Type,
pubmed-meshheading:10623848-Mice,
pubmed-meshheading:10623848-Mice, Inbred BALB C,
pubmed-meshheading:10623848-Mice, Inbred C57BL,
pubmed-meshheading:10623848-Molecular Sequence Data,
pubmed-meshheading:10623848-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:10623848-Peptide Fragments,
pubmed-meshheading:10623848-Protein Biosynthesis,
pubmed-meshheading:10623848-Proteins,
pubmed-meshheading:10623848-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10623848-Salmonella Infections, Animal,
pubmed-meshheading:10623848-Salmonella typhimurium,
pubmed-meshheading:10623848-T-Lymphocyte Subsets
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pubmed:year |
2000
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pubmed:articleTitle |
Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium.
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pubmed:affiliation |
Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. mcsor00@tc.umn.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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