| pubmed-article:10622714 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10622714 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10622714 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:10622714 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:10622714 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:10622714 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:10622714 | lifeskim:mentions | umls-concept:C1816452 | lld:lifeskim |
| pubmed-article:10622714 | lifeskim:mentions | umls-concept:C0332282 | lld:lifeskim |
| pubmed-article:10622714 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:10622714 | lifeskim:mentions | umls-concept:C1516044 | lld:lifeskim |
| pubmed-article:10622714 | lifeskim:mentions | umls-concept:C0063220 | lld:lifeskim |
| pubmed-article:10622714 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10622714 | pubmed:dateCreated | 2000-2-2 | lld:pubmed |
| pubmed-article:10622714 | pubmed:abstractText | Hypericin (HY) is a powerful photo-inducer of apoptosis in Jurkat cells as measured by caspase-3 activation, cell shrinkage, phosphatidylserine (PS) exposure and the appearance of hypoploid DNA. These processes are preceded by rapid Bcl-2-independent mitochondrial transmembrane depolarization and a drop in cytoplasmic pH. Pre-incubation of cells with inhibitors of the mitochondrial permeability transition pore, such as cyclosporin A or bongkrekic acid, does not protect cells from mitochondrial membrane potential (deltapsim) decrease. However, monitoring of mitochondrial entrapped calcein by confocal fluorescence imaging gives clear evidence of HY photo-induced mitochondrial permeability. This should be considered as the result of a non-specific alteration of mitochondrial membrane integrity brought about by lipid peroxidation. Nevertheless, synthesis of the anti-apoptotic protein Bcl-2 appears to delay the subsequent time course of PS exposure and to reduce caspase-3 activation and the fraction of cells which become hypoploid. We interpret this partially protective effect as the consequence of a direct interaction of Bcl-2 with cytosolic cytochrome c previously released from mitochondria upon deltapsim decrease and/or of Bcl-2 inhibition of the deleterious retro-effect of caspase-3 on the mitochondrial permeability transition pore and/or the mitochondrial membrane components. | lld:pubmed |
| pubmed-article:10622714 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10622714 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10622714 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10622714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10622714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10622714 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10622714 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10622714 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:10622714 | pubmed:author | pubmed-author:ChaloupkaRR | lld:pubmed |
| pubmed-article:10622714 | pubmed:author | pubmed-author:IsraëlNN | lld:pubmed |
| pubmed-article:10622714 | pubmed:author | pubmed-author:SureauFF | lld:pubmed |
| pubmed-article:10622714 | pubmed:author | pubmed-author:PetitP XPX | lld:pubmed |
| pubmed-article:10622714 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10622714 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:10622714 | pubmed:volume | 462 | lld:pubmed |
| pubmed-article:10622714 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10622714 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10622714 | pubmed:pagination | 295-301 | lld:pubmed |
| pubmed-article:10622714 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10622714 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10622714 | pubmed:articleTitle | Over-expression of Bcl-2 does not protect cells from hypericin photo-induced mitochondrial membrane depolarization, but delays subsequent events in the apoptotic pathway. | lld:pubmed |
| pubmed-article:10622714 | pubmed:affiliation | Laboratoire de Physicochimie Biomoléculaire et Cellulaire (CNRS ESA 7033), Université P. et M. Curie, Paris, France. | lld:pubmed |
| pubmed-article:10622714 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10622714 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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