Source:http://linkedlifedata.com/resource/pubmed/id/10622347
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2000-2-8
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pubmed:abstractText |
Amisulpride, a substituted benzamide with high selectivity for dopamine D3 and D2 receptors, was compared with the antipsychotic risperidone in patients with acute exacerbations of schizophrenia. The study was double-blind and involved 228 patients allocated, after a 3-6-day wash-out period, to amisulpride 800 mg (n = 115) or risperidone 8 mg (n = 113) for 8 weeks. Both treatments produced a marked improvement in schizophrenic symptomatology. Decreases in mean BPRS total score were 17.7 +/- 14.9 for amisulpride and 15.2 +/- 13.9 for risperidone, and all of the individual factors on the BPRS showed a numerically greater improvement in the amisulpride than in the risperidone patients. Both treatments were equally effective against positive symptoms on the PANSS positive syndrome subscale; however, there was a trend in favor of greater improvement in negative symptoms assessed on the PANSS negative subscale in patients receiving amisulpride with a decrease of 6.9 +/- 7.5 vs. 5.3 +/- 6.6 for risperidone (P = 0.09). Both drugs demonstrated good safety profiles, and scores on neurological scales (SAS, AIMS, and BAS) did not increase during treatment. A comparable proportion of patients received antiparkinsonian medication, 30 and 23% in the amisulpride and risperidone groups, respectively (P = 0.21). Patients receiving risperidone experienced an increase in body weight, which was significantly greater than for amisulpride (P = 0.026).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0165-1781
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
107-17
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pubmed:dateRevised |
2008-4-17
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pubmed:meshHeading |
pubmed-meshheading:10622347-Acute Disease,
pubmed-meshheading:10622347-Adult,
pubmed-meshheading:10622347-Antipsychotic Agents,
pubmed-meshheading:10622347-Body Weight,
pubmed-meshheading:10622347-Double-Blind Method,
pubmed-meshheading:10622347-Female,
pubmed-meshheading:10622347-Humans,
pubmed-meshheading:10622347-Male,
pubmed-meshheading:10622347-Middle Aged,
pubmed-meshheading:10622347-Psychiatric Status Rating Scales,
pubmed-meshheading:10622347-Remission Induction,
pubmed-meshheading:10622347-Risperidone,
pubmed-meshheading:10622347-Schizophrenia,
pubmed-meshheading:10622347-Sulpiride,
pubmed-meshheading:10622347-Treatment Outcome
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pubmed:year |
1999
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pubmed:articleTitle |
Amisulpride vs. risperidone in the treatment of acute exacerbations of schizophrenia. Amisulpride study group.
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pubmed:affiliation |
Psychiatrisch Instituut, U.C. Sint Jozef, Kortenberg, Belgium.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Multicenter Study
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