Source:http://linkedlifedata.com/resource/pubmed/id/10620540
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-1-12
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pubmed:abstractText |
Verotoxin-producing Escherichia coli (VTEC) cause hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). The aim of this study was to compare the circulating levels of transforming growth factor-beta 1 (TGF-beta1), T helper (T(H))1 (interferon [IFN]-gamma, interleukin [IL]-2), and T(H)2-associated lymphokines (IL-4, IL-13) in children with uncomplicated Escherichia coli O157:H7 HC and patients who developed HUS. Circulating levels of IL-2, IL-4, and IL-13 were undetectable, and those of IFN-gamma were low and comparable among groups. Concentrations of TGF-beta1 were higher in children with uncomplicated O157:H7 HC than among those who developed HUS (934 +/- 680 versus 514 +/- 497 pg/mL, respectively; P < 0.04). The circulating levels of TGF-beta1 were also higher among children who did not take antidiarrheal agents (P < 0.008) and those who have been immediately discharged from the emergency room (P < 0.03). Our results did not show an imbalanced T(H)1/T(H)2-associated lymphokine response during the development of HUS. Increased circulating levels of TGF-beta1 in children with milder O157:H7 or uncomplicated HC most likely reflect appropriate intestinal tissue repair mechanisms rather than a remote systemic endocrine effect on the kidneys.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1523-6838
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-34
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10620540-Adolescent,
pubmed-meshheading:10620540-Child,
pubmed-meshheading:10620540-Child, Preschool,
pubmed-meshheading:10620540-Colitis,
pubmed-meshheading:10620540-Escherichia coli Infections,
pubmed-meshheading:10620540-Escherichia coli O157,
pubmed-meshheading:10620540-Female,
pubmed-meshheading:10620540-Hemolytic-Uremic Syndrome,
pubmed-meshheading:10620540-Humans,
pubmed-meshheading:10620540-Infant,
pubmed-meshheading:10620540-Lymphocyte Count,
pubmed-meshheading:10620540-Lymphokines,
pubmed-meshheading:10620540-Male,
pubmed-meshheading:10620540-Th1 Cells,
pubmed-meshheading:10620540-Th2 Cells,
pubmed-meshheading:10620540-Transforming Growth Factor beta
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pubmed:year |
2000
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pubmed:articleTitle |
Circulating levels of transforming growth factor-beta1 and lymphokines among children with hemolytic uremic syndrome.
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pubmed:affiliation |
Department of Pediatrics, Sainte-Justine Hospital, University of Montreal, Montreal, Canada. sip@point-net.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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