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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2000-1-27
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pubmed:abstractText |
The association of transcription corepressors SMRT and N-CoR with retinoid and thyroid receptors results in suppression of basal transcriptional activity. A key event in nuclear receptor signaling is the hormone-dependent release of corepressor and the recruitment of coactivator. Biochemical and structural studies have identified a universal motif in coactivator proteins that mediates association with receptor LBDs. We report here the identity of complementary acting signature motifs in SMRT and N-CoR that are sufficient for receptor binding and ligand-induced release. Interestingly, the motif contains a hydrophobic core (PhixxPhiPhi) similar to that found in NR coactivators. Surprisingly, mutations in the amino acids that directly participate in coactivator binding disrupt the corepressor association. These results indicate a direct mechanistic link between activation and repression via competition for a common or at least partially overlapping binding site.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-10454590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-642007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-7481822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-7566114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-7566127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-8521507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-8521508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-8548460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-8616895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-8643509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-8752277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-8755515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-8855229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-8948627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9030683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9122185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9139820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9139821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9150133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9150134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9150135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9150137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9192892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9192902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9267036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9620851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9744270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9808622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10617570-9875847
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GAL4 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Co-Repressor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Galactosidase
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3209-16
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10617570-Animals,
pubmed-meshheading:10617570-Fungal Proteins,
pubmed-meshheading:10617570-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:10617570-Amino Acid Sequence,
pubmed-meshheading:10617570-Binding Sites,
pubmed-meshheading:10617570-Cell Line,
pubmed-meshheading:10617570-beta-Galactosidase,
pubmed-meshheading:10617570-Molecular Sequence Data,
pubmed-meshheading:10617570-Nuclear Proteins,
pubmed-meshheading:10617570-Protein Structure, Secondary,
pubmed-meshheading:10617570-Cloning, Molecular,
pubmed-meshheading:10617570-Repressor Proteins,
pubmed-meshheading:10617570-Signal Transduction,
pubmed-meshheading:10617570-DNA-Binding Proteins,
pubmed-meshheading:10617570-Receptors, Thyroid Hormone,
pubmed-meshheading:10617570-Transcription Factors,
pubmed-meshheading:10617570-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:10617570-Receptors, Retinoic Acid,
pubmed-meshheading:10617570-Recombinant Fusion Proteins,
pubmed-meshheading:10617570-DNA Mutational Analysis,
pubmed-meshheading:10617570-Nuclear Receptor Co-Repressor 1
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