Source:http://linkedlifedata.com/resource/pubmed/id/10617077
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
24
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pubmed:dateCreated |
2000-2-3
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pubmed:abstractText |
Dicarba-closo-dodecaboranes (carboranes), which have spherical geometry and hydrophobicity, are applicable as a hydrophobic pharmacophore of biologically active molecules. We have designed and synthesized estrogenic antagonists based on the structure of the potent agonist 1-hydroxymethyl-12-(4-hydroxyphenyl)-1,12-dicarba-closo-d odecaborane, which we have developed. The compounds showed potent antagonistic activity in luciferase reporter gene assay using COS-1 cells transfected with rat ER alpha-expression plasmid and an appropriate reporter plasmid.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3387-92
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10617077-Animals,
pubmed-meshheading:10617077-Boron Compounds,
pubmed-meshheading:10617077-COS Cells,
pubmed-meshheading:10617077-Estrogen Antagonists,
pubmed-meshheading:10617077-Genes, Reporter,
pubmed-meshheading:10617077-Luciferases,
pubmed-meshheading:10617077-Models, Molecular,
pubmed-meshheading:10617077-Rats
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pubmed:year |
1999
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pubmed:articleTitle |
Estrogenic antagonists bearing dicarba-closo-dodecaborane as a hydrophobic pharmacophore.
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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