Source:http://linkedlifedata.com/resource/pubmed/id/10616911
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2000-1-21
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| pubmed:abstractText |
Serotonin (5-HT) is pruritogenic in humans and suggested to be involved in some pruritic diseases. Our experiments were carried out to determine whether an intradermal injection of 5-HT would elicit itch-associated response in mice and to elucidate the 5-HT receptor subtypes involved in this 5-HT action. 5-HT (14.1-235 nmol site(-1)) injected intradermally into the rostral back elicited scratching of the injected site, with bell-shaped dose-response relationship. The scratching induced by 5-HT (100 nmol site(-1), peak effective dose) was suppressed by capsaicin (repeated administration) and the opioid antagonist naloxone, features being similar to human itching. Scratching was also elicited by the 5-HT2 receptor agonist alpha-methylserotonin, but not by the 5-HT1A receptor agonist R(+)-8-hydroxy-N,N-dipropyl-2-aminotetralin nor the 5-HT3 receptor agonists 2-methylserotonin and 1-phenylbiganide. Scratching induced by 5-HT and alpha-methylserotonin was inhibited by peroral pretreatment with 5-HT1/2 receptor antagonists methysergide and cyproheptadine. 5-HT-induced scratching was also inhibited by intradermal injection of methysergide. Peroral pretreatment with 5-HT3 receptor antagonists ondansetron and 3-tropanyl-3, 5-dichrobenzoate did not significantly suppress 5-HT-induced scratching. The results suggest that scratching induced by intradermal injection of 5-HT is itch-associated response. The 5-HT action may be mediated at least partly by cutaneous 5-HT2 receptors.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
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| pubmed:issn |
0168-0102
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
77-83
|
| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:10616911-Analysis of Variance,
pubmed-meshheading:10616911-Animals,
pubmed-meshheading:10616911-Behavior, Animal,
pubmed-meshheading:10616911-Capsaicin,
pubmed-meshheading:10616911-Dose-Response Relationship, Drug,
pubmed-meshheading:10616911-Histamine,
pubmed-meshheading:10616911-Injections, Intradermal,
pubmed-meshheading:10616911-Male,
pubmed-meshheading:10616911-Mice,
pubmed-meshheading:10616911-Mice, Inbred Strains,
pubmed-meshheading:10616911-Naloxone,
pubmed-meshheading:10616911-Narcotic Antagonists,
pubmed-meshheading:10616911-Pruritus,
pubmed-meshheading:10616911-Reaction Time,
pubmed-meshheading:10616911-Receptors, Serotonin,
pubmed-meshheading:10616911-Serotonin,
pubmed-meshheading:10616911-Serotonin Antagonists,
pubmed-meshheading:10616911-Serotonin Receptor Agonists
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| pubmed:year |
1999
|
| pubmed:articleTitle |
Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice.
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| pubmed:affiliation |
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|